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Transdermal diffusion of resveratrol by multilamellar liposomes: Effect of encapsulation on its stability

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAFARGE, Eulalie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorVILLETTE, Sandrine
dc.contributor.authorCARIO-ANDRE, Muriel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLECOMTE, Sophie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFAURE, Chrystel
dc.date.accessioned2023-04-18T08:16:34Z
dc.date.available2023-04-18T08:16:34Z
dc.date.issued2022-10-01
dc.identifier.issn1773-2247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173041
dc.description.abstractEnTrans-Resveratrol (RV) was encapsulated in multi-lamellar liposomes (MLLs) composed of a mixture of phosphatidylcholine (P100), Tween 80 (T80) and water. The P100-to-T80 ratio as well as their water content were chosen based on a previous study to promote transdermal transport of RV. The effect of RV on the size, elasticity, and charge of MLLs was evaluated as well as the effect of encapsulation on the apparent solubility of RV. The diffusion of RV and MLLs in artificial skin, namely Strat-M™, was monitored by confocal Raman imaging, and compared with that of a RV solution and empty MLLs, while the transdermal passage rate was measured by UV–vis spectrophotometry on both artificial and excised human skin. RV was found to remain localized in the outer layer of the skin with less than 3% passing through it over a 24-h period in both skin types. Encapsulation in MLLs drastically increased its transdermal passage: 73 ± 10% after 3 h of incubation on excised human skin, and 10% on Strat-M™ after 9 h. Whereas RV in its free form underwent cis isomerization, MLLs protected it up to 9h before undergoing chemical degradation after 24h.
dc.language.isoENen_US
dc.title.enTransdermal diffusion of resveratrol by multilamellar liposomes: Effect of encapsulation on its stability
dc.title.alternativeJournal of Drug Delivery Science and Technologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jddst.2022.103742en_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGYen_US
bordeaux.volume76en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04072466
hal.version1
hal.date.transferred2023-04-18T08:16:36Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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