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Microstructural Gray Matter Integrity Deteriorates After an Ischemic Stroke and Is Associated with Processing Speed

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSAGNIER, Sharmila
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCATHELINE, Gwenaelle
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDILHARREGUY, Bixente
dc.contributor.authorLINCK, Pierre-Antoine
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorCOUPE, Pierrick
dc.contributor.authorPOLI, Mathilde
dc.contributor.authorMUNSCH, Fanny
dc.contributor.authorBIGOURDAN, Antoine
dc.contributor.authorDEBRUXELLES, Sabrina
dc.contributor.authorRENOU, Pauline
dc.contributor.authorOLINDO, Stephane
dc.contributor.authorROUANET, Francois
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSIBON, Igor
dc.date.accessioned2023-03-17T13:22:07Z
dc.date.available2023-03-17T13:22:07Z
dc.date.issued2022-04-18
dc.identifier.issn1868-4483en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172345
dc.description.abstractEnMicrostructural changes after an ischemic stroke (IS) have mainly been described in white matter. Data evaluating microstructural changes in gray matter (GM) remain scarce. The aim of the present study was to evaluate the integrity of GM on longitudinal data using mean diffusivity (MD), and its influence on post-IS cognitive performances. A prospective study was conducted, including supra-tentorial IS patients without pre-stroke disability. A cognitive assessment was performed at baseline and 1 year, including a Montreal Cognitive Assessment, an Isaacs set test, and a Zazzo cancelation task (ZCT): completion time and number of errors. A 3-T brain MRI was performed at the same two time-points, including diffusion tensor imaging for the assessment of GM MD. GM volume was also computed, and changes in GM volume and GM MD were evaluated, followed by the assessment of the relationship between these structural changes and changes in cognitive performances. One hundred and four patients were included (age 68.5 ± 21.5, 38.5% female). While no GM volume loss was observed, GM MD increased between baseline and 1 year. The increase of GM MD in left fronto-temporal regions (dorsolateral prefrontal cortex, superior and medial temporal gyrus, p < 0.05, Threshold-Free Cluster Enhancement, 5000 permutations) was associated with an increase time to complete ZCT, regardless of demographic confounders, IS volume and location, GM, and white matter hyperintensity volume. GM integrity deterioration was thus associated with processing speed slowdown, and appears to be a biomarker of cognitive frailty. This broadens the knowledge of post-IS cognitive impairment mechanisms. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoENen_US
dc.subject.enDiffusion tensor imaging
dc.subject.enGray matter
dc.subject.enProcessing speed
dc.subject.enStroke
dc.subject.enLongitudinal
dc.title.enMicrostructural Gray Matter Integrity Deteriorates After an Ischemic Stroke and Is Associated with Processing Speed
dc.title.alternativeTransl Stroke Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s12975-022-01020-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35437660en_US
bordeaux.journalTranslational stroke researchen_US
bordeaux.page1-8en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.institutionBordeaux INP
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.funder.anrTranslational Research and Advanced Imaging Laboratory
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Translational%20stroke%20research&amp;rft.date=2022-04-18&amp;rft.spage=1-8&amp;rft.epage=1-8&amp;rft.eissn=1868-4483&amp;rft.issn=1868-4483&amp;rft.au=SAGNIER,%20Sharmila&amp;CATHELINE,%20Gwenaelle&amp;DILHARREGUY,%20Bixente&amp;LINCK,%20Pierre-Antoine&amp;COUPE,%20Pierrick&amp;rft.genre=article


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