Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB] | |
| dc.contributor.author | PETRIA, Iulia | |
| hal.structure.identifier | Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)] | |
| dc.contributor.author | ALBUQUERQUE, Samuel | |
| hal.structure.identifier | Méthodes computationnelles et mathématiques pour comprendre la société et la santé à partir de données [SODA] | |
| dc.contributor.author | VAROQUAUX, Gaël | |
| hal.structure.identifier | Méthodes computationnelles et mathématiques pour comprendre la société et la santé à partir de données [SODA] | |
| dc.contributor.author | VIE, Jill-Jênn | |
| hal.structure.identifier | Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)] | |
| dc.contributor.author | VENTECLEF, Nicolas | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| hal.structure.identifier | Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)] | |
| dc.contributor.author | ROUSSEL, Ronan | |
| hal.structure.identifier | Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP] | |
| dc.contributor.author | CAMOIN, Marion | |
| hal.structure.identifier | Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB] | |
| dc.contributor.author | PERSEGHIN, Gianluca | |
| hal.structure.identifier | Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)] | |
| dc.contributor.author | VELHO, Gilberto | |
| hal.structure.identifier | Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)] | |
| dc.contributor.author | POTIER, Louis | |
| dc.date.accessioned | 2023-03-09T13:49:28Z | |
| dc.date.available | 2023-03-09T13:49:28Z | |
| dc.date.issued | 2022-11-17 | |
| dc.identifier.issn | 1475-2840 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172234 | |
| dc.description.abstractEn | Cardiovascular risk and body-weight management are both emerging challenges of type 1 diabetes care. We evaluated the association between intraindividual variability of body-weight and risk of cardiovascular events in people with type 1 diabetes. We analyzed 1,398 participants from the DCCT/EDIC studies. Five indices of intraindividual variability of body-weight were calculated for each participant taking into account body-weight measures obtained during the DCCT follow-up (average 6 ± 2 years). The Average Successive Variability (ASV) index, the main variable of interest, was defined as the average absolute difference between successive body-weight measures. The primary outcome was a composite of major adverse cardiovascular events (MACE: nonfatal myocardial infarction or stroke, or cardiovascular death) occurring during the subsequent EDIC follow-up (20 ± 3 years). All-cause death was a secondary outcome. Risk of outcomes were assessed by Cox proportional hazards regression analyses, adjusted for traditional cardiovascular risks factors, including BMI. The cumulative incidence of MACE and all-cause death during follow-up were 5.6% (n = 79) and 6.8% (n = 95), respectively. The adjusted Hazard Ratio (HR) for MACE by every increase of 1 standard deviation (SD) of ASV was 1.34 (95% CI, 1.06-1.66), p = 0.01. For all-cause death, the adjusted HR for 1 SD increase of ASV was 1.25 (1.03-1.50), p = 0.03. Similar results were observed when considering the other indices of intraindividual variability of body-weight. High body-weight variability (body-weight cycling) is associated with increased risk of MACE and all-cause death in people with type 1 diabetes, independently of the BMI and traditional cardiovascular risk factors. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject | Article clinique | |
| dc.subject.en | Humans | |
| dc.subject.en | Diabetes Mellitus | |
| dc.subject.en | Type 1 | |
| dc.subject.en | Retrospective Studies | |
| dc.subject.en | Risk Factors | |
| dc.subject.en | Cardiovascular System | |
| dc.subject.en | Body Weight | |
| dc.subject.en | Myocardial Infarction | |
| dc.title.en | Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population. | |
| dc.title.alternative | Cardiovasc Diabetol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12933-022-01689-0 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 36397092 | en_US |
| bordeaux.journal | Cardiovascular Diabetology | en_US |
| bordeaux.page | 247 | en_US |
| bordeaux.volume | 21 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04021480 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-03-09T13:49:31Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cardiovascular%20Diabetology&rft.date=2022-11-17&rft.volume=21&rft.issue=1&rft.spage=247&rft.epage=247&rft.eissn=1475-2840&rft.issn=1475-2840&rft.au=PETRIA,%20Iulia&ALBUQUERQUE,%20Samuel&VAROQUAUX,%20Ga%C3%ABl&VIE,%20Jill-J%C3%AAnn&VENTECLEF,%20Nicolas&rft.genre=article |
