Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LESPINASSE, Jeremie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHENE, Genevieve | |
| dc.contributor.author | MANGIN, Jean-Francois | |
| dc.contributor.author | DUBOIS, Bruno | |
| dc.contributor.author | BLANC, Frederic | |
| dc.contributor.author | PAQUET, Claire | |
| dc.contributor.author | HANON, Olivier | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | PLANCHE, Vincent | |
| dc.contributor.author | GABELLE, Audrey | |
| dc.contributor.author | CECCALDI, Mathieu | |
| dc.contributor.author | ANNWEILER, Cedric | |
| dc.contributor.author | KROLAK-SALMON, Pierre | |
| dc.contributor.author | GODEFROY, Olivier | |
| dc.contributor.author | WALLON, David | |
| dc.contributor.author | SAUVEE, Mathilde | |
| dc.contributor.author | BERGERET, Sebastien | |
| dc.contributor.author | CHUPIN, Marie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile | |
| dc.contributor.author | DUFOUIL, Carole | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUFOUIL, Carole | |
| dc.contributor.author | GROUP, For The MEMENTO Study | |
| dc.date.accessioned | 2023-03-07T09:02:21Z | |
| dc.date.available | 2023-03-07T09:02:21Z | |
| dc.date.issued | 2023-06 | |
| dc.identifier.issn | 1552-5279 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172194 | |
| dc.description.abstractEn | Introduction Approximately 40% of dementia cases could be delayed or prevented acting on modifiable risk factors including hypertension. However, the mechanisms underlying the hypertension–dementia association are still poorly understood. Methods We conducted a cross-sectional analysis in 2048 patients from the MEMENTO cohort, a French multicenter clinic-based study of outpatients with either isolated cognitive complaints or mild cognitive impairment. Exposure to hypertension was defined as a combination of high blood pressure (BP) status and antihypertensive treatment intake. Pathway associations were examined through structural equation modeling integrating extensive collection of neuroimaging biomarkers and clinical data. Results Participants treated with high BP had significantly lower cognition compared to the others. This association was mediated by higher neurodegeneration and higher white matter hyperintensities load but not by Alzheimer's disease (AD) biomarkers. Discussion These results highlight the importance of controlling hypertension for prevention of cognitive decline and offer new insights on mechanisms underlying the hypertension–dementia association. Highlights Paths of hypertension–cognition association were assessed by structural equation models. The hypertension–cognition association is not mediated by Alzheimer's disease biomarkers. The hypertension–cognition association is mediated by neurodegeneration and leukoaraiosis. Lower cognition was limited to participants treated with uncontrolled blood pressure. Blood pressure control could contribute to promote healthier brain aging. | |
| dc.description.sponsorship | Stopping cognitive decline and dementia by fighting covert cerebral small vessel disease | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | amyloid beta 42 | |
| dc.subject.en | cognition | |
| dc.subject.en | cortical thickness | |
| dc.subject.en | fluorodeoxyglucose positron emission tomography | |
| dc.subject.en | hippocampal volume | |
| dc.subject.en | hypertension | |
| dc.subject.en | mediation | |
| dc.subject.en | positron emission tomography amyloid | |
| dc.subject.en | structural equation model | |
| dc.subject.en | tau | |
| dc.subject.en | white matter hyperintensities | |
| dc.title.en | Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.12866 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36464896 | en_US |
| bordeaux.journal | Alzheimer's and Dementia | en_US |
| bordeaux.page | 2332-2342 | |
| bordeaux.volume | 19 | |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 6 | |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2023-06&rft.volume=19&rft.issue=6&rft.spage=2332-2342&rft.epage=2332-2342&rft.eissn=1552-5279&rft.issn=1552-5279&rft.au=LESPINASSE,%20Jeremie&CHENE,%20Genevieve&MANGIN,%20Jean-Francois&DUBOIS,%20Bruno&BLANC,%20Frederic&rft.genre=article |
