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Associations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLESPINASSE, Jeremie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorMANGIN, Jean-Francois
dc.contributor.authorDUBOIS, Bruno
dc.contributor.authorBLANC, Frederic
dc.contributor.authorPAQUET, Claire
dc.contributor.authorHANON, Olivier
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorPLANCHE, Vincent
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorCECCALDI, Mathieu
dc.contributor.authorANNWEILER, Cedric
dc.contributor.authorKROLAK-SALMON, Pierre
dc.contributor.authorGODEFROY, Olivier
dc.contributor.authorWALLON, David
dc.contributor.authorSAUVEE, Mathilde
dc.contributor.authorBERGERET, Sebastien
dc.contributor.authorCHUPIN, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
dc.contributor.authorDUFOUIL, Carole
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorGROUP, For The MEMENTO Study
dc.date.accessioned2023-03-07T09:02:21Z
dc.date.available2023-03-07T09:02:21Z
dc.date.issued2023-06
dc.identifier.issn1552-5279en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172194
dc.description.abstractEnIntroduction Approximately 40% of dementia cases could be delayed or prevented acting on modifiable risk factors including hypertension. However, the mechanisms underlying the hypertension–dementia association are still poorly understood. Methods We conducted a cross-sectional analysis in 2048 patients from the MEMENTO cohort, a French multicenter clinic-based study of outpatients with either isolated cognitive complaints or mild cognitive impairment. Exposure to hypertension was defined as a combination of high blood pressure (BP) status and antihypertensive treatment intake. Pathway associations were examined through structural equation modeling integrating extensive collection of neuroimaging biomarkers and clinical data. Results Participants treated with high BP had significantly lower cognition compared to the others. This association was mediated by higher neurodegeneration and higher white matter hyperintensities load but not by Alzheimer's disease (AD) biomarkers. Discussion These results highlight the importance of controlling hypertension for prevention of cognitive decline and offer new insights on mechanisms underlying the hypertension–dementia association. Highlights Paths of hypertension–cognition association were assessed by structural equation models. The hypertension–cognition association is not mediated by Alzheimer's disease biomarkers. The hypertension–cognition association is mediated by neurodegeneration and leukoaraiosis. Lower cognition was limited to participants treated with uncontrolled blood pressure. Blood pressure control could contribute to promote healthier brain aging.
dc.description.sponsorshipStopping cognitive decline and dementia by fighting covert cerebral small vessel diseaseen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enamyloid beta 42
dc.subject.encognition
dc.subject.encortical thickness
dc.subject.enfluorodeoxyglucose positron emission tomography
dc.subject.enhippocampal volume
dc.subject.enhypertension
dc.subject.enmediation
dc.subject.enpositron emission tomography amyloid
dc.subject.enstructural equation model
dc.subject.entau
dc.subject.enwhite matter hyperintensities
dc.title.enAssociations among hypertension, dementia biomarkers, and cognition: The MEMENTO cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12866en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36464896en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.page2332-2342
bordeaux.volume19
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamPHARES_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20and%20Dementia&rft.date=2023-06&rft.volume=19&rft.issue=6&rft.spage=2332-2342&rft.epage=2332-2342&rft.eissn=1552-5279&rft.issn=1552-5279&rft.au=LESPINASSE,%20Jeremie&CHENE,%20Genevieve&MANGIN,%20Jean-Francois&DUBOIS,%20Bruno&BLANC,%20Frederic&rft.genre=article


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