Pharmaco-virological algorithm to target risk of drug resistance among a population of HIV-infected key populations in Togo
| dc.rights.license | open | en_US |
| dc.contributor.author | FERRE, Valentine M. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BITTY-ANDERSON, Alexandra | |
| dc.contributor.author | PEYTAVIN, Gilles | |
| dc.contributor.author | LE, Minh P. | |
| dc.contributor.author | DAGNRA, Claver A. | |
| dc.contributor.author | COPPEE, Romain | |
| dc.contributor.author | GBEASOR-KOMLANVI, Fifonsi A. | |
| dc.contributor.author | DESCAMPS, Diane | |
| dc.contributor.author | CHARPENTIER, Charlotte | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | EKOUEVI, Didier Koumavi | |
| dc.date.accessioned | 2023-02-22T08:32:19Z | |
| dc.date.available | 2023-02-22T08:32:19Z | |
| dc.date.issued | 2023-01-27 | |
| dc.identifier.issn | 1096-9071 (Electronic) 0146-6615 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/172049 | |
| dc.description.abstractEn | BACKGROUND: No data about ARV treatment coverage and virological response are available among key populations (female sex workers [FSW] and MSM) in Togo. This study aimed to both describe HIV immuno-virological status and evaluate the pertinence of an original algorithm combining pharmacology (PK) and viral load (VL) to identify subjects at risk of ARV drug resistance. METHODS: A cross-sectional multicentric study was conducted in 2017 in Togo. Our PK-virological algorithm (PK-VA) defines subjects at risk of resistance when exhibiting both detectable plasma drug concentrations and VL>200 c/mL. RESULTS: Among the 123 FSW and 136 MSM included, 50% and 66% were receiving ARV, with 69% and 80% of them successfully-treated, respectively. Genotypes showed drug-resistance mutation (DRM) in 58% and 63% of non-virologically controlled (VL >200 c/mL) ARV-treated FSW and MSM, respectively. PK-VA would have enabled to save 75% and 72% of genotypic tests, for FSW and MSM, respectively. CONCLUSION: We reported first data about HIV care cascade among key populations in Togo, highlighting they are tested for HIV but linkage to care remains a concern. Furthermore, 70-80% of ARV-treated participants experienced virological success. In limited resources settings, where genotyping tests are beyond reach, PK-VA might be an easiest solution to sort out patients needing ARV adaptation due to resistance. This article is protected by copyright. All rights reserved. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Africa | |
| dc.subject.en | ARV resistance | |
| dc.subject.en | FSW | |
| dc.subject.en | HIV | |
| dc.subject.en | MSM | |
| dc.subject.en | Togo | |
| dc.title.en | Pharmaco-virological algorithm to target risk of drug resistance among a population of HIV-infected key populations in Togo | |
| dc.title.alternative | J Med Virol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/jmv.28535 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36708093 | en_US |
| bordeaux.journal | Journal of Medical Virology | en_US |
| bordeaux.volume | 95 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | GHIGS_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Recherches sur le Sida et les Hépatites Virales | en_US |
| hal.identifier | hal-04000040 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-07-05T09:28:44Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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