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Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns

dc.rights.licenseopenen_US
dc.contributor.authorESTEBAN-CANTOS, Andres
dc.contributor.authorRODRIGUEZ-CENTENO, Javier
dc.contributor.authorSILLA, Juan C.
dc.contributor.authorBARRUZ, Pilar
dc.contributor.authorSANCHEZ-CABO, Fatima
dc.contributor.authorSAIZ-MEDRANO, Gabriel
dc.contributor.authorNEVADO, Julian
dc.contributor.authorMENA-GARAY, Beatriz
dc.contributor.authorJIMENEZ-GONZALEZ, Maria
dc.contributor.authorDE MIGUEL, Rosa
dc.contributor.authorBERNARDINO, Jose I.
dc.contributor.authorMONTEJANO, Rocio
dc.contributor.authorCADINANOS, Julen
dc.contributor.authorMARCELO, Cristina
dc.contributor.authorGUTIERREZ-GARCIA, Lucia
dc.contributor.authorMARTINEZ-MARTIN, Patricia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWALLET, Cedrick
dc.contributor.authorRAFFI, Francois
dc.contributor.authorRODES, Berta
dc.contributor.authorARRIBAS, Jose R.
dc.date.accessioned2023-02-22T08:25:54Z
dc.date.available2023-02-22T08:25:54Z
dc.date.issued2023-02
dc.identifier.issn2352-3964 (Electronic) 2352-3964 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172047
dc.description.abstractEnBACKGROUND: Previous epigenome-wide association studies have shown that HIV infection can disrupt the host DNA methylation landscape. However, it remains unclear how antiretroviral therapy (ART) affects the HIV-induced epigenetic modifications. METHODS: 184 individuals with HIV from the NEAT001/ANRS143 clinical trial (with pre-ART and post-ART samples [96 weeks of follow-up]) and 44 age-and-sex matched individuals without HIV were included. We compared genome-wide DNA methylation profiles in whole blood between groups adjusting for age, sex, batch effects, and DNA methylation-based estimates of leucocyte composition. FINDINGS: We identified 430 differentially methylated positions (DMPs) between HIV+ pre-ART individuals and HIV-uninfected controls. In participants with HIV, ART initiation modified the DNA methylation levels at 845 CpG positions and restored 49.3% of the changes found between HIV+ pre-ART and HIV-uninfected individuals. We only found 15 DMPs when comparing DNA methylation profiles between HIV+ post-ART individuals and participants without HIV. The Gene Ontology enrichment analysis of DMPs associated with untreated HIV infection revealed an enrichment in biological processes regulating the immune system and antiviral responses. In participants with untreated HIV infection, DNA methylation levels at top HIV-related DMPs were associated with CD4/CD8 ratios and viral loads. Changes in DNA methylation levels after ART initiation were weakly correlated with changes in CD4+ cell counts and the CD4/CD8 ratio. INTERPRETATION: Control of HIV viraemia after 96 weeks of ART initiation partly restores the host DNA methylation changes that occurred before antiretroviral treatment of HIV infection. FUNDING: NEAT-ID Foundation and Instituto de Salud Carlos III, co-funded by European Union.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enHIV infection
dc.subject.enEpigenetics
dc.subject.enGenome-wide DNA methylation
dc.subject.enAntiretroviral therapy
dc.title.enEffect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
dc.title.alternativeEBioMedicineen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ebiom.2022.104434en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36640455en_US
bordeaux.journalEBioMedicineen_US
bordeaux.volume88en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04000027
hal.version1
hal.date.transferred2023-02-22T08:26:16Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EBioMedicine&rft.date=2023-02&rft.volume=88&rft.eissn=2352-3964%20(Electronic)%202352-3964%20(Linking)&rft.issn=2352-3964%20(Electronic)%202352-3964%20(Linking)&rft.au=ESTEBAN-CANTOS,%20Andres&RODRIGUEZ-CENTENO,%20Javier&SILLA,%20Juan%20C.&BARRUZ,%20Pilar&SANCHEZ-CABO,%20Fatima&rft.genre=article


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