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Diabetic Retinopathy Relates to the Incidence of Foot Ulcers and Amputations in Type 2 Diabetes

dc.rights.licenseopenen_US
dc.contributor.authorBORDERIE, Gauthier
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorFOUSSARD, Ninon
dc.contributor.authorLARROUMET, Alice
dc.contributor.authorBLANCO, Laurence
dc.contributor.authorBARBET-MASSIN, Marie-Amelie
dc.contributor.authorDUCOS, Claire
dc.contributor.authorRIGO, Marine
dc.contributor.authorARAB, Lila Rami
dc.contributor.authorDOMENGE, Frederic
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorDUCASSE, Eric
dc.contributor.authorCARADU, Caroline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535
IDREF: 028739272
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
dc.date.accessioned2023-02-15T08:44:35Z
dc.date.available2023-02-15T08:44:35Z
dc.date.issued2023-03
dc.identifier.issn1520-7552en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171950
dc.description.abstractEnWe investigated whether Diabetic Retinopathy (DR) is related to Diabetic Foot Ulcers (DFU) development, adjusted for the stratification of the International Work Group on Diabetic Foot (IWGDF) guidance. DR and IWGDF stratification were registered retrospectively in patients hospitalized from 2009 to 2017 for uncontrolled and/or complicated type 2 diabetes. New DFUs were registered until 2020. Survival analyses categorized the subjects for DR, and multivariate Cox regression adjusted for confounders. The 522 patients (57.9% male) were 62±9 years old, with a diabetes duration of 14±10 years, HbA1c of 8.7±1.8%, 33.9% macroangiopathies and 44.8% diabetic kidney diseases. Their grades of DFU risk were 0 for 43.3%, 1 for 23.9%, 2 for 7.1%, and 3 for 25.6%. During the 52 months follow-up (IQR: 32-71), 58 new DFUs and 18 lower-limb amputations occurred, mostly in patients with DR present in 140 (26.8%) patients. Adjusted for age, sex and conventional risk factors (duration and control of diabetes, arterial hypertension, dyslipidemia), and other complications (macroangiopathy, diabetic kidney disease), DR associated with a greater incidence of DFUs. Adjusted for the IWGDF classification, DR was related to new DFUs (HR: 2.51, 95%CI: 1.48-4.26) and amputations (HR: 3.56, 95%CI: 1.26-10.07). This relationship persisted in ascending IWGDF grades, with incidences of DFUs from 2/1000 (grade 0, no DR) to 121/1000 patient-years (grade 3 and DR), and amputations from 0 (grade 0, no DR) to 38/1000 patient-years (grade 3 and DR). Diabetic retinopathy independently relates to the incidence of foot ulcers and amputations in patients hospitalized for type 2 diabetes. This article is protected by copyright. All rights reserved.
dc.language.isoENen_US
dc.subject.enDiabetic foot ulcer
dc.subject.enDiabetic retinopathy
dc.subject.enType 2 diabetes
dc.title.enDiabetic Retinopathy Relates to the Incidence of Foot Ulcers and Amputations in Type 2 Diabetes
dc.title.alternativeDiabetes Metab Res Reven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/dmrr.3605en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36575816en_US
bordeaux.journalDiabetes/Metabolism Research and Reviewsen_US
bordeaux.volume39
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03989864
hal.version1
hal.date.transferred2023-02-15T08:44:48Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes/Metabolism%20Research%20and%20Reviews&rft.date=2023-03&rft.volume=39&rft.issue=3&rft.eissn=1520-7552&rft.issn=1520-7552&rft.au=BORDERIE,%20Gauthier&FOUSSARD,%20Ninon&LARROUMET,%20Alice&BLANCO,%20Laurence&BARBET-MASSIN,%20Marie-Amelie&rft.genre=article


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