Afficher la notice abrégée

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLEE, Thomas H.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUARTA, Carmelo
dc.date.accessioned2023-02-06T13:38:20Z
dc.date.available2023-02-06T13:38:20Z
dc.date.created2022
dc.date.issued2022
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171874
dc.description.abstractEnObesity is a chronic and debilitating disorder that originates from alterations in energy-sensing brain circuits controlling body weight gain and food intake. The dysregulated syntheses and actions of lipid mediators in the hypothalamus induce weight gain and overfeeding, but the molecular and cellular underpinnings of these alterations remain elusive. In response to changes in the nutritional status, different lipid sensing pathways in the hypothalamus direct body energy needs in a Yin-Yang model. Endocannabinoids orchestrate the crosstalk between hypothalamic circuits and the sympathetic nervous system to promote food intake and energy accumulation during fasting, whereas bile acids act on the same top-down axis to reduce energy intake and possibly storage after the meal. In obesity, the bioavailability and downstream cellular actions of endocannabinoids and bile acids are altered in hypothalamic neurons involved in body weight and metabolic control. Thus, the onset and progression of this disease might result from an imbalance in hypothalamic sensing of multiple lipid signals, which are possibly integrated by common molecular nodes. In this viewpoint, we discuss a possible model that explains how bile acids and endocannabinoids may exert their effects on energy balance regulation via interconnected mechanisms at the level of the hypothalamic neuronal circuits. Therefore, we propose a new conceptual framework for understanding and treating central mechanisms of maladaptive lipid action in obesity. © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
dc.description.sponsorshipRôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésitéen_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscienceen_US
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeuren_US
dc.description.sponsorshipLa signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique - ANR-17-CE14-0007en_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. - ANR-18-CE14-0029en_US
dc.description.sponsorshipRôle du circuit POMC-striatum ventral dans le développement de l'obésité - ANR-21-CE14-0018en_US
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003en_US
dc.language.isoENen_US
dc.subject.enObesity
dc.subject.enEndocannabinoids
dc.subject.enBile acids
dc.subject.enHypothalamus
dc.subject.enLipid metabolism
dc.title.enYin-Yang control of energy balance by lipids in the hypothalamus: The endocannabinoids vs bile acids case
dc.title.alternativeBiochimieen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biochi.2022.07.006en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35863558en_US
bordeaux.journalBiochimie
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDSociété Française d’Endocrinologieen_US
hal.identifierhal-03975295
hal.version1
hal.date.transferred2023-02-06T13:38:23Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimie&rft.date=2022&rft.au=LEE,%20Thomas%20H.&COTA,%20Daniela&QUARTA,%20Carmelo&rft.genre=article


Fichier(s) constituant ce document

Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée