Afficher la notice abrégée

Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia

dc.rights.licenseopenen_US
dc.contributor.authorSALLES, Jérôme
dc.contributor.authorCHANET, Audrey
dc.contributor.authorGUILLET, Christelle
dc.contributor.authorVAES, Anouk MM
dc.contributor.authorBROUWER-BROLSMA, Elske M.
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorROCHER, Christophe
dc.contributor.authorGIRAUDET, Christophe
dc.contributor.authorPATRAC, Véronique
dc.contributor.authorMEUGNIER, Emmanuelle
dc.contributor.authorMONTAURIER, Christophe
dc.contributor.authorDENIS, Philippe
dc.contributor.authorLE BACQUER, Olivier
dc.contributor.authorBLOT, Adeline
dc.contributor.authorJOURDAN, Marion
dc.contributor.authorLUIKING, Yvette
dc.contributor.authorFURBER, Matthew
dc.contributor.authorVAN DIJK, Miriam
dc.contributor.authorTARDIF, Nicolas
dc.contributor.authorYVES BOIRIE, Y.
dc.contributor.authorWALRAND, Stéphane
dc.date.accessioned2023-01-24T13:21:49Z
dc.date.available2023-01-24T13:21:49Z
dc.date.issued2022-11-24
dc.identifier.issn2399-3642en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171760
dc.description.abstractEnSkeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP production from oxidative phosphorylation. We aimed to examine the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects. To gain further insight into the mechanisms involved, we used C2C12 and human muscle cells and transgenic mice with muscle-specific VDR tamoxifen-inducible deficiency. We observed that in vivo and in vitro vitamin D fluctuations changed mitochondrial biogenesis and oxidative activity in skeletal muscle. Vitamin D supplementation initiated in older people improved muscle mass and strength. We hypothesize that vitamin D supplementation is likely to help prevent not only sarcopenia but also sarcopenic obesity in vitamin D-deficient subjects.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enNutrition disorders
dc.subject.enCalcium and vitamin D
dc.title.enVitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
dc.title.alternativeCommun Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s42003-022-04246-3en_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaireen_US
bordeaux.journalCommunications Biologyen_US
bordeaux.page1-15en_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesLaboratoire de Biogenèse Membranaire (LBM) - UMR 5200en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Communications%20Biology&rft.date=2022-11-24&rft.volume=5&rft.issue=1&rft.spage=1-15&rft.epage=1-15&rft.eissn=2399-3642&rft.issn=2399-3642&rft.au=SALLES,%20J%C3%A9r%C3%B4me&CHANET,%20Audrey&GUILLET,%20Christelle&VAES,%20Anouk%20MM&BROUWER-BROLSMA,%20Elske%20M.&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
LBM_CommunBio_2022_Salles.pdf
Taille:
2.238Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée