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Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner

dc.rights.licenseopenen_US
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
dc.contributor.authorCOSTA, Alessia
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
dc.contributor.authorRANI, Barbara
hal.structure.identifierUniversity College Cork [UCC]
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorBASTIAANSSEN, Thomaz F.S.
hal.structure.identifierNEUROFARBA Department [Firenze, Italy]
dc.contributor.authorBONFIGLIO, Francesco
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorGUNNIGLE, Eoin
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
hal.structure.identifierNEUROFARBA Department [Firenze, Italy]
dc.contributor.authorPROVENSI, Gustavo
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorROSSITTO, Moira
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorBOEHME, Marcus
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorSTRAIN, Conall
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorMARTINEZ, Clara S.
hal.structure.identifierNEUROFARBA Department [Firenze, Italy]
dc.contributor.authorBLANDINA, Patrizio
hal.structure.identifierUniversity College Cork [UCC]
hal.structure.identifierAPC Microbiome Ireland
dc.contributor.authorCRYAN, John F.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNEUROFARBA Department [Firenze, Italy]
dc.contributor.authorCORRADETTI, Renato
hal.structure.identifierUniversità degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
dc.contributor.authorPASSANI, Maria Beatrice
dc.date.accessioned2023-01-19T12:51:37Z
dc.date.available2023-01-19T12:51:37Z
dc.date.issued2022-01-13
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171741
dc.description.abstractEnExposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. Histaminergic neurotransmission has a central role in orchestrating specific behavioural responses depending on the homeostatic state of a subject, but it remains to be established if it participates in the protective effects against the insults of chronic stress afforded by a healthy diet. By using C57BL/6J male mice that do not synthesize histamine (Hdc−/−) and their wild type (Hdc+/+) congeners we evaluated if the histaminergic system participates in the protective action of a diet enriched with polyunsaturated fatty acids and vitamin A on the deleterious effect of chronic stress. Behavioural tests across domains relevant to cognition and anxiety were performed. Hippocampal synaptic plasticity, cytokine expression, hippocampal fatty acids, oxylipins and microbiota composition were also assessed. Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc−/− and Hdc+/+ mice. Dietary enrichment counteracted stress-induced deficits only in Hdc+/+ mice as histamine deficiency prevented almost all of the diet-related beneficial effects. Interpretation: Our results reveal a previously unexplored and novel role for brain histamine as a mediator of many favorable effects of the enriched diet. These data present long-reaching perspectives in the field of nutritional neuropsychopharmacology. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHdc null mice
dc.subject.enn-3 LC-PUFA
dc.subject.enLong-term potentiation
dc.subject.enOxylipins
dc.subject.enSocial avoidance
dc.title.enDiet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms23020862en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35055048en_US
bordeaux.journalInternational journal of molecular sciencesen_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.identifierhal-03946871
hal.version1
hal.date.transferred2023-01-19T12:51:49Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.date=2022-01-13&rft.volume=23&rft.issue=2&rft.eissn=1661-6596&rft.issn=1661-6596&rft.au=COSTA,%20Alessia&RANI,%20Barbara&BASTIAANSSEN,%20Thomaz%20F.S.&BONFIGLIO,%20Francesco&GUNNIGLE,%20Eoin&rft.genre=article


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