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Dietary Long‐Chain n‐3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice

dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDI MICELI, Mathieu
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTINAT, Maud
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorROSSITTO, Moira
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
hal.structure.identifierKing Abdulaziz University
dc.contributor.authorALASHMALI, Shoug
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJOFFRE, Corinne
hal.structure.identifierKing Abdulaziz University
dc.contributor.authorBAZINET, Richard P.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.date.accessioned2023-01-19T10:24:50Z
dc.date.available2023-01-19T10:24:50Z
dc.date.issued2022-06-14
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171737
dc.description.abstractEnLong‐chain (LC) n‐3 polyunsaturated fatty acids (PUFAs) have drawn attention in the field of neuropsychiatric disorders, in particular depression. However, whether dietary supplementation with LC n‐3 PUFA protects from the development of mood disorders is still a matter of de-bate. In the present study, we studied the effect of a two‐month exposure to isocaloric diets containing n‐3 PUFAs in the form of relatively short‐chain (SC) (6% of rapeseed oil, enriched in α‐linolenic acid (ALA)) or LC (6% of tuna oil, enriched in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) PUFAs on behavior and synaptic plasticity of mice submitted or not to a chronic social defeat stress (CSDS), previously reported to alter emotional and social behavior, as well as synaptic plasticity in the nucleus accumbens (NAc). First, fatty acid content and lipid metabolism gene expression were measured in the NAc of mice fed a SC (control) or LC n‐3 (supplemented) PUFA diet. Our results indicate that LC n‐3 supplementation significantly increased some n‐3 PUFAs, while decreasing some n‐6 PUFAs. Then, in another cohort, control and n‐3 PUFA‐supplemented mice were subjected to CSDS, and social and emotional behaviors were assessed, together with long‐term depression plasticity in accumbal medium spiny neurons. Overall, mice fed with n‐3 PUFA supple-mentation displayed an emotional behavior profile and electrophysiological properties of medium spiny neurons which was distinct from the ones displayed by mice fed with the control diet, and this, independently of CSDS. Using the social interaction index to discriminate resilient and suscep-tible mice in the CSDS groups, n‐3 supplementation promoted resiliency. Altogether, our results pinpoint that exposure to a diet rich in LC n‐3 PUFA, as compared to a diet rich in SC n‐3 PUFA, influences the NAc fatty acid profile. In addition, electrophysiological properties and emotional behavior were altered in LC n‐3 PUFA mice, independently of CSDS. Our results bring new insights about the effect of LC n‐3 PUFA on emotional behavior and synaptic plasticity. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enDHA
dc.subject.enEPA
dc.subject.enALA
dc.subject.enChronic social defeat stress
dc.subject.enLipid microarray
dc.subject.enWhole-cell patch-clamp electrophysiology
dc.subject.enLong-term depression
dc.subject.enEmotional behavior
dc.title.enDietary Long‐Chain n‐3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms23126650en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35743093en_US
bordeaux.journalInternational journal of molecular sciencesen_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnementen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.date=2022-06-14&rft.volume=23&rft.issue=12&rft.eissn=1661-6596&rft.issn=1661-6596&rft.au=DI%20MICELI,%20Mathieu&MARTINAT,%20Maud&ROSSITTO,%20Moira&AUBERT,%20Agnes&ALASHMALI,%20Shoug&rft.genre=article


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