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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTIN, Hugo
hal.structure.identifierCentre de Recherches sur la Cognition Animale - UMR5169 [CRCA]
hal.structure.identifierCentre de Biologie Intégrative [CBI]
dc.contributor.authorBULLICH, Sebastien
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARTINAT, Maud
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCHATAIGNER, Mathilde
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDI MICELI, Mathieu
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSIMON, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCLARK, Samantha
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBUTLER, Jasmine
dc.contributor.authorSCHELL, Mareike
dc.contributor.authorCHOPRA, Simran
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCHAOULOFF, Francis
dc.contributor.authorKLEINRIDDERS, Andre
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDE DEURWAERDERE, Philippe
hal.structure.identifierGeroscience and rejuvenation research center [RESTORE]
dc.contributor.authorPENICAUD, Luc
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
hal.structure.identifierCentre de Recherches sur la Cognition Animale - UMR5169 [CRCA]
hal.structure.identifierCentre de Biologie Intégrative [CBI]
dc.contributor.authorGUIARD, Bruno P.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFIORAMONTI, Xavier
dc.date.accessioned2022-12-22T13:58:20Z
dc.date.available2022-12-22T13:58:20Z
dc.date.issued2022-10-07
dc.identifier.issn1359-4184en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171591
dc.description.abstractEnType-2 Diabetes (T2D) is characterized by insulin resistance and accompanied by psychiatric comorbidities including major depressive disorders (MDD). Patients with T2D are twice more likely to suffer from MDD and clinical studies have shown that insulin resistance is positively correlated with the severity of depressive symptoms. However, the potential contribution of central insulin signaling in MDD in patients with T2D remains elusive. Here we hypothesized that insulin modulates the serotonergic (5-HT) system to control emotional behavior and that insulin resistance in 5-HT neurons contributes to the development of mood disorders in T2D. Our results show that insulin directly modulates the activity of dorsal raphe (DR) 5-HT neurons to dampen 5-HT neurotransmission through a 5-HT1A receptor-mediated inhibitory feedback. In addition, insulin-induced 5-HT neuromodulation is necessary to promote anxiolytic-like effect in response to intranasal insulin delivery. Interestingly, such an anxiolytic effect of intranasal insulin as well as the response of DR 5-HT neurons to insulin are both blunted in high-fat diet-fed T2D animals. Altogether, these findings point to a novel mechanism by which insulin directly modulates the activity of DR 5-HT neurons to dampen 5-HT neurotransmission and control emotional behaviors, and emphasize the idea that impaired insulin-sensitivity in these neurons is critical for the development of T2D-associated mood disorders. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
dc.description.sponsorshipLa signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métaboliqueen_US
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.en_US
dc.language.isoENen_US
dc.title.enInsulin modulates emotional behavior through a serotonin-dependent mechanism
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41380-022-01812-3en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36207585en_US
bordeaux.journalMolecular Psychiatryen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03910983
hal.version1
hal.date.transferred2022-12-22T13:58:25Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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