| dc.rights.license | open | en_US |
| dc.contributor.author | LOPEZ-GAMBERO, Antonio J. | |
| dc.contributor.author | PACHECO-SANCHEZ, Beatriz | |
| dc.contributor.author | ROSELL-VALLE, Cristina | |
| dc.contributor.author | MEDINA-VERA, Dina | |
| dc.contributor.author | NAVARRO, Juan Antonio | |
| dc.contributor.author | DEL MAR FERNANDEZ-ARJONA, Maria | |
| dc.contributor.author | DE CEGLIA, Marialuisa | |
| dc.contributor.author | SANJUAN, Carlos | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | SIMON, Vincent | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| dc.contributor.author | RIVERA, Patricia | |
| dc.contributor.author | RODRIGUEZ DE FONSECA, Fernando | |
| dc.contributor.author | SUAREZ, Juan | |
| dc.date.accessioned | 2022-12-20T16:38:34Z | |
| dc.date.available | 2022-12-20T16:38:34Z | |
| dc.date.issued | 2022-06 | |
| dc.identifier.issn | 0753-3322 | en_US |
| dc.identifier.other | doi:10.1016/j.biopha.2022.112994 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171586 | |
| dc.description.abstractEn | Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study aimed to determine the effect of oral dietary administration of D-Chiro-inositol (DCI), an inositol used against insulin resistance associated with polycystic ovary, on the occurrence of metabolic disorders in the transgenic 5xFAD mouse model of AD (FAD: Family Alzheimer's Disease). DCI was administered from 6 to 10 months of age to male and female 5xFAD mice and control (non-Tg) littermates. Energy balance and multiple metabolic and inflammatory parameters in the hypothalamus, liver and plasma were evaluated to assess the central and peripheral effects of DCI. Results indicated that weight loss and reduced food intake in 5xFAD mice were associated with decreased neuropeptides controlling food intake and the appearance of a pro-inflammatory state in the hypothalamus. Oral administration of DCI partially restored energy balance and hypothalamic parameters, highlighting an increased expression of Npy and Agrp and female-specific downregulation of Gfap and Igf1. DCI also partially normalized impaired insulin signaling and circulating insulin, GLP-1, and GIP deficiencies in 5xFAD mice. Principal component analysis of metabolic parameters indicated the presence of a female-specific fatty liver in 5xFAD mice: DCI administration reversed hepatic fat accumulation, β-oxidation, inflammation and increased GOT and GPT levels. Our study depicts that metabolic impairment along with the cognitive decline in a mouse model of AD, which is exacerbated in females, can be ameliorated by oral supplementation with insulin-sensitizing DCI. © 2022 The Authors | |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur | en_US |
| dc.description.sponsorship | La signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique | en_US |
| dc.description.sponsorship | Rôle du circuit POMC-striatum ventral dans le développement de l'obésité | en_US |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Alzheimer’s disease | |
| dc.subject.en | D-chiro-inositol | |
| dc.subject.en | Fatty liver disease | |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Insulin signaling | |
| dc.title.en | Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease | |
| dc.title.alternative | Biomed Pharmacother | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biopha.2022.112994 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35483188 | en_US |
| dc.description.sponsorshipEurope | Defining a Roadmap for Cooperative Health research between the EU and Latin America-Caribbean countries: a Policy Oriented Approach | en_US |
| bordeaux.journal | Biomedicine & pharmacotherapy | en_US |
| bordeaux.page | 112994 | en_US |
| bordeaux.volume | 150 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | European Regional Development Fund | en_US |
| bordeaux.identifier.funderID | Ministerio de Economía y Competitividad | en_US |
| bordeaux.identifier.funderID | Instituto de Salud Carlos III | en_US |
| hal.identifier | hal-03908669 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-12-20T16:38:51Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.date=2022-06&rft.volume=150&rft.spage=112994&rft.epage=112994&rft.eissn=0753-3322&rft.issn=0753-3322&rft.au=LOPEZ-GAMBERO,%20Antonio%20J.&PACHECO-SANCHEZ,%20Beatriz&ROSELL-VALLE,%20Cristina&MEDINA-VERA,%20Dina&NAVARRO,%20Juan%20Antonio&rft.genre=article | |
