Afficher la notice abrégée

A synaptomic analysis reveals dopamine hub synapses in the mouse striatum

dc.rights.licenseopenen_US
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorPAGET BLANC, Vincent
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorPFEFFER, Marlene
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorPRONOT, Marie
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorLAPIOS, Paul
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorANGELO, Maria Florencia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorWALLE, Roman
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorCORDELIERES, Fabrice
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorLEVET, Florian
hal.structure.identifierPlateforme Protéome [Bordeaux]
dc.contributor.authorCLAVEROL, Stephane
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorLACOMME, Sabrina
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorPETREL, Melina
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorMARTIN, Christelle
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorPITARD, Vincent
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDE SMEDT PEYRUSSE, Veronique
dc.contributor.authorBIEDERER, Thomas
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorPERRAIS, David
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorHERZOG, Etienne
dc.date.accessioned2022-12-19T10:01:35Z
dc.date.available2022-12-19T10:01:35Z
dc.date.issued2022-06-03
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171574
dc.description.abstractEnDopamine transmission is involved in reward processing and motor control, and its impairment plays a central role in numerous neurological disorders. Despite its strong pathophysiological relevance, the molecular and structural organization of the dopaminergic synapse remains to be established. Here, we used targeted labelling and fluorescence activated sorting to purify striatal dopaminergic synaptosomes. We provide the proteome of dopaminergic synapses with 57 proteins specifically enriched. Beyond canonical markers of dopamine neurotransmission such as dopamine biosynthetic enzymes and cognate receptors, we validated 6 proteins not previously described as enriched. Moreover, our data reveal the adhesion of dopaminergic synapses to glutamatergic, GABAergic or cholinergic synapses in structures we named “dopamine hub synapses”. At glutamatergic synapses, pre- and postsynaptic markers are significantly increased upon association with dopamine synapses. Dopamine hub synapses may thus support local dopaminergic signalling, complementing volume transmission thought to be the major mechanism by which monoamines modulate network activity. © 2022, The Author(s).
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeauxen_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnéeen_US
dc.description.sponsorshipImpact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivationen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enA synaptomic analysis reveals dopamine hub synapses in the mouse striatum
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-022-30776-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35660742en_US
bordeaux.journalNature Communicationsen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2022-06-03&rft.volume=13&rft.issue=1&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=PAGET%20BLANC,%20Vincent&PFEFFER,%20Marlene&PRONOT,%20Marie&LAPIOS,%20Paul&ANGELO,%20Maria%20Florencia&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
NutriNeuro_NatCommun_2022_Page ...
Taille:
5.694Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée