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Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

dc.rights.licenseopenen_US
hal.structure.identifierVilnius University [Vilnius]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorLENGVENYTE, Aiste
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierHôpital Princesse Grace [Monaco]
dc.contributor.authorAUBIN, Valerie
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Princesse Grace [Monaco]
dc.contributor.authorLOFTUS, Josephine
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierGroupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
dc.contributor.authorMARLINGE, Emeline
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGARD, Sebastien
hal.structure.identifierCentre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSCHWAN, Raymund
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLLORCA, Pierre-Michel
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPASSERIEUX, Christine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorROUX, Paul
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorPOLOSAN, Mircea
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorETAIN, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorFONDAMENTAL, Advanced, Centers, Of, Expertise, In, Bipolar, Disorders, (FACE-BD), Collaborators
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorOLIE, Emilie
dc.date.accessioned2022-12-12T09:47:34Z
dc.date.available2022-12-12T09:47:34Z
dc.date.issued2022-01-01
dc.identifier.issn0165-0327en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170551
dc.description.abstractEnBackground: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD. Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report. Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p <.001, p =.014, and p =.006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00–1.05, p =.018; Exp(B) 2.16, CI 1.00–4.64, p =.009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA. Limitations: Cross-sectional design and retrospective reporting. Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA. © 2021 Elsevier B.V.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enSuicide
dc.subject.enBipolar disorder
dc.subject.enObesity
dc.subject.enCognitive function
dc.subject.enMemory
dc.subject.enCohort
dc.title.enViolent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2021.09.097en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34606799en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page265-276en_US
bordeaux.volume296en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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