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The Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis

dc.rights.licenseopenen_US
hal.structure.identifierColumbia University Irving Medical Center [CUIMC]
dc.contributor.authorKEARNEY-RAMOS, Tonisha
hal.structure.identifierNational Institute on Drug Abuse [NIH, Bethesda, USA] [NIDA]
dc.contributor.authorHERRMANN, Evan S.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLUOMO, Ilaria
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMATIAS, Isabel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVALLEE, Monique
dc.contributor.authorMONLEZUN, Stephanie
dc.contributor.authorPIAZZA, Pier Vincenzo
hal.structure.identifierColumbia University Irving Medical Center [CUIMC]
dc.contributor.authorHANEY, Margaret
dc.date.accessioned2022-12-08T11:15:58Z
dc.date.available2022-12-08T11:15:58Z
dc.date.created2022-04-29
dc.date.issued2022-04-29
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170505
dc.description.abstractEnBackground: The endogenous cannabinoid system (ECS), including the endocannabinoids (eCBs), anandamide (AEA), and 2-arachidonoylglycerol (2-AG), plays an integral role in psychophysiological functions. Although frequent cannabis use is associated with adaptations in the ECS, the impact of acute smoked cannabis administration on circulating eCBs, and the relationship between cannabis effects and circulating eCBs are poorly understood.Methods: This study measured the plasma levels of AEA, 2-AG, and Δ-9-tetrahydrocannabinol (THC), subjective drug-effects ratings, and cardiovascular measures at baseline and 15–180 min after cannabis users (n=26) smoked 70% of a cannabis cigarette (5.6% THC).Results: Cannabis administration increased the ratings of intoxication, heart rate, and plasma THC levels relative to baseline. Although cannabis administration did not affect eCB levels relative to baseline, there was a significant positive correlation between baseline AEA levels and peak ratings of “High” and “Good Drug Effect.” Further, baseline 2-AG levels negatively correlated with frequency of cannabis use (mean days/week) and with baseline THC metabolite levels.Conclusions: In a subset of heavy cannabis smokers: (1) more frequent cannabis use was associated with lower baseline 2-AG, and (2) those with lower AEA got less intoxicated after smoking cannabis. These findings contribute to a sparse literature on the interaction between endo- and phyto-cannabinoids. Future studies in participants with varied cannabis use patterns are needed to clarify the association between circulating eCBs and the abuse-related effects of cannabis, and to test whether baseline eCBs predict the intoxicating effects of cannabis and are a potential biomarker of cannabis tolerance.
dc.language.isoENen_US
dc.subject.en2-Arachidonoylglycerol
dc.subject.enanandamide
dc.subject.enendocannabinoid
dc.subject.encannabis use disorder
dc.subject.enplasma concentration
dc.subject.ensubjective effects
dc.title.enThe Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis
dc.title.alternativeCannabis Cannabinoid Resen_US
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1089/can.2021.0185en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologieen_US
dc.subject.halSciences du Vivant [q-bio]/Toxicologieen_US
dc.identifier.pubmed35486827en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie et approches thérapeutiques des maladies liées au stressen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.import.sourcehal
hal.identifierhal-03821434
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2022-04-29&rft.au=KEARNEY-RAMOS,%20Tonisha&HERRMANN,%20Evan%20S.&BELLUOMO,%20Ilaria&MATIAS,%20Isabel&VALLEE,%20Monique&rft.genre=preprint


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