| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LODS, Marie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MORTESSAGNE, Pierre | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PACARY, Emilie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TERRAL, Geoffrey | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | FARRUGIA, Fanny | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MAZIER, Wilfrid | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MASACHS, Nuria | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CHARRIER, Vanessa | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FERREIRA, Guillaume | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ABROUS, Nora | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TRONEL, Sophie | |
| dc.date.accessioned | 2022-12-08T11:05:46Z | |
| dc.date.available | 2022-12-08T11:05:46Z | |
| dc.date.issued | 2022-12 | |
| dc.identifier.issn | 0301-0082 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170502 | |
| dc.description.abstractEn | Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of adult neurogenesis is a sufficient condition to improve memory performance remains unclear. Here, we developed and validated, using ex-vivo electrophysiology, a chemogenetic approach that combines selective tagging and activation of discrete adult-born neuron populations. Then we demonstrated that, in rats, this activation can improve accuracy and strength of remote memory. These results show that stimulation of adult-born neuron activity can counteract the natural fading of memory traces that occurs with the passage of time. This opens up new avenues for treating memory problems that may arise over time. | |
| dc.description.sponsorship | Rôle de la neurogénèse hippocampique dans la reconsolidation de la mémoire - ANR-16-CE37-0018 | en_US |
| dc.description.sponsorship | Dissection des mécanismes hypothalamiques impliqués dans la détection du statut nutritionnel et régulation de la prise alimentaire via les interactions entre mTORC1, les mélanocortines et les endocannabinoïdes. | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Adult neurogenesis | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Memory | |
| dc.subject.en | Chemogenetic | |
| dc.title.en | Chemogenetic stimulation of adult neurogenesis, and not neonatal neurogenesis, is sufficient to improve long-term memory accuracy | |
| dc.title.alternative | Prog Neurobiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.pneurobio.2022.102364 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie | en_US |
| dc.identifier.pubmed | 36244613 | en_US |
| bordeaux.journal | Progress in Neurobiology | en_US |
| bordeaux.page | 102364 | en_US |
| bordeaux.volume | 219 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | INRAE | |
| bordeaux.team | Neurogénèse et physiopathologie | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.team | Physiopathologie de la mémoire déclarative | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03837190 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Progress%20in%20Neurobiology&rft.date=2022-12&rft.volume=219&rft.spage=102364&rft.epage=102364&rft.eissn=0301-0082&rft.issn=0301-0082&rft.au=LODS,%20Marie&MORTESSAGNE,%20Pierre&PACARY,%20Emilie&TERRAL,%20Geoffrey&FARRUGIA,%20Fanny&rft.genre=article | |
