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The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria

dc.rights.licenseopenen_US
dc.contributor.authorDALLE, Celine
dc.contributor.authorTOURNAYRE, Jeremy
dc.contributor.authorMAINKA, Malwina
dc.contributor.authorBASIAK-RASALA, Alicja
dc.contributor.authorPETERA, Melanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorDALLOUX-CHIOCCIOLI, Jessica
dc.contributor.authorDESCHASAUX-TANGUY, Melanie
dc.contributor.authorLECUYER, Lucie
dc.contributor.authorKESSE-GUYOT, Emmanuelle
dc.contributor.authorFEZEU, Leopold K.
dc.contributor.authorHERCBERG, Serge
dc.contributor.authorGALAN, Pilar
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorZATONSKA, Katarzyna
dc.contributor.authorCALDER, Philip C.
dc.contributor.authorFIIL HJORTH, Mads
dc.contributor.authorASTRUP, Arne
dc.contributor.authorMAZUR, Andre
dc.contributor.authorBERTRAND-MICHEL, Justine
dc.contributor.authorSCHEBB, Nils Helge
dc.contributor.authorSZUBA, Andrzej
dc.contributor.authorTOUVIER, Mathilde
dc.contributor.authorNEWMAN, John W.
dc.contributor.authorGLADINE, Cecile
dc.date.accessioned2022-12-07T08:49:28Z
dc.date.available2022-12-07T08:49:28Z
dc.date.issued2022-10-02
dc.identifier.issn1422-0067 (Electronic) 1422-0067 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170489
dc.description.abstractEnMetabolic syndrome (MetS) is a complex condition encompassing a constellation of cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating many cardiometabolic functions. Plasma oxylipin signature could provide a new clinical tool to enhance the phenotyping of MetS pathophysiology. A high-throughput validated mass spectrometry method, allowing for the quantitative profiling of over 130 oxylipins, was applied to identify and validate the oxylipin signature of MetS in two independent nested case/control studies involving 476 participants. We identified an oxylipin signature of MetS (coined OxyScore), including 23 oxylipins and having high performances in classification and replicability (cross-validated AUC(ROC) of 89%, 95% CI: 85-93% and 78%, 95% CI: 72-85% in the Discovery and Replication studies, respectively). Correlation analysis and comparison with a classification model incorporating the MetS criteria showed that the oxylipin signature brings consistent and complementary information to the clinical criteria. Being linked with the regulation of various biological processes, the candidate oxylipins provide an integrative phenotyping of MetS regarding the activation and/or negative feedback regulation of crucial molecular pathways. This may help identify patients at higher risk of cardiometabolic diseases. The oxylipin signature of patients with metabolic syndrome enhances MetS phenotyping and may ultimately help to better stratify the risk of cardiometabolic diseases.
dc.description.sponsorshipOxylipins signature to monitor the cardiometabolic status and its response to dietary interventionen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enOxylipins
dc.subject.enLipid mediators
dc.subject.enLipidomics
dc.subject.enMetabolic syndrome
dc.subject.enMetabolic phenotyping
dc.title.enThe Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms231911688en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36232991en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue19en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2022-10-02&rft.volume=23&rft.issue=19&rft.eissn=1422-0067%20(Electronic)%201422-0067%20(Linking)&rft.issn=1422-0067%20(Electronic)%201422-0067%20(Linking)&rft.au=DALLE,%20Celine&TOURNAYRE,%20Jeremy&MAINKA,%20Malwina&BASIAK-RASALA,%20Alicja&PETERA,%20Melanie&rft.genre=article


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