Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease
| dc.rights.license | open | en_US |
| hal.structure.identifier | Laboratoire des Maladies Neurodégénératives - UMR 9199 [LMN] | |
| dc.contributor.author | BONVENTO, Gilles | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | OLIET, Stéphane | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PANATIER, Aude | |
| dc.date.accessioned | 2022-12-01T09:04:02Z | |
| dc.date.available | 2022-12-01T09:04:02Z | |
| dc.date.issued | 2022-05-03 | |
| dc.identifier.issn | 1550-4131 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1016/j.cmet.2022.04.002 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170441 | |
| dc.description.abstractEn | Recent work from Bonvento and colleagues indicated that synaptic and memory deficits in early Alzheimer's disease (AD) are related to a shortage in L-serine production in astrocytes. Here, the authors, responding to correspondence from Chen and colleagues, discuss how this deficiency does not necessarily require a decrease in PHGDH expression and conclude that the primary event leading to lower serine production is more likely related to altered glycolytic flux in early AD than to PHGDH expression. | |
| dc.language.iso | EN | en_US |
| dc.source | crossref | |
| dc.subject.en | Alzheimer Disease / metabolism | |
| dc.subject.en | Astrocytes / metabolism | |
| dc.subject.en | Glycolysis | |
| dc.subject.en | Humans | |
| dc.subject.en | Phosphoglycerate Dehydrogenase / metabolism | |
| dc.subject.en | Serine / metabolism | |
| dc.title.en | Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease | |
| dc.title.alternative | Cell Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.cmet.2022.04.002 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35508106 | en_US |
| bordeaux.journal | Cell Metabolism | en_US |
| bordeaux.page | 654-655 | en_US |
| bordeaux.volume | 34 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.export | false | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Metabolism&rft.date=2022-05-03&rft.volume=34&rft.issue=5&rft.spage=654-655&rft.epage=654-655&rft.eissn=1550-4131&rft.issn=1550-4131&rft.au=BONVENTO,%20Gilles&OLIET,%20St%C3%A9phane&PANATIER,%20Aude&rft.genre=article |
