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dc.rights.licenseopenen_US
dc.contributor.authorMARGIANI, Giulia
dc.contributor.authorCASTELLI, Maria Paola
dc.contributor.authorPINTORI, Nicholas
dc.contributor.authorFRAU, Roberto
dc.contributor.authorENNAS, Maria Grazia
dc.contributor.authorORRU, Roberto
dc.contributor.authorSERRA, Valentina
dc.contributor.authorFIORILLO, Edoardo
dc.contributor.authorFADDA, Paola
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.contributor.authorDE LUCA, Maria Antonietta
dc.date.accessioned2022-11-07T13:50:45Z
dc.date.available2022-11-07T13:50:45Z
dc.date.issued2022-10
dc.identifier.issn0000-3158en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170217
dc.description.abstractEnRationale: The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among adolescents, posing major medical and psychiatric risks. JWH-018 represents the reference compound of SCRA-containing products. Objectives: This study was performed to evaluate the enduring consequences of adolescent voluntary consumption of JWH-018. Methods: The reinforcing properties of JWH-018 were characterized in male CD1 adolescent mice by intravenous self-administration (IVSA). Afterwards, behavioral, neurochemical, and molecular evaluations were performed at adulthood. Results: Adolescent mice acquired operant behavior (lever pressing, Fixed Ratio 1–3; 7.5 µg/kg/inf); this behavior was specifically directed at obtaining JWH-018 since it increased under Progressive Ratio schedule of reinforcement, and was absent in vehicle mice. JWH-018 IVSA was reduced by pretreatment of the CB1-antagonist/inverse agonist AM251. Adolescent exposure to JWH-018 by IVSA increased, at adulthood, both nestlet shredding and marble burying phenotypes, suggesting long-lasting repetitive/compulsive-like behavioral effects. JWH-018 did not affect risk proclivity in the wire-beam bridge task. In adult brains, there was an increase of ionized calcium binding adaptor molecule 1 (IBA-1) positive cells in the caudate-putamen (CPu) and nucleus accumbens (NAc), along with a decrease of glial fibrillary acidic protein (GFAP) immunoreactivity in the CPu. These glial alterations in adult brains were coupled with an increase of the chemokine RANTES and a decrease of the cytokines IL2 and IL13 in the cortex, and an increase of the chemokine MPC1 in the striatum. Conclusions: This study suggests for the first time that male mice self-administer the prototypical SCRA JWH-018 during adolescence. The adolescent voluntary consumption of JWH-018 leads to long-lasting behavioral and neurochemical aberrations along with glia-mediated inflammatory responses in adult brains. © 2022, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.en3 (1 Naphthoyl) 1 Pentylindole
dc.subject.en6 Iodo 3 (4 Methoxybenzoyl) 2 Methyl 1 (2 Morpholinoethyl)Indole
dc.subject.enAdaptor Protein
dc.subject.enCannabinoid 1 Receptor
dc.subject.enCyclooxygenase 2
dc.subject.enExcitatory Amino Acid Transporter 2
dc.subject.enGlial Fibrillary Acidic Protein
dc.subject.enInterleukin 2
dc.subject.enInterleukin 3
dc.subject.enIonized Calcium Binding Adaptor Molecule 1
dc.subject.enMonocyte Chemotactic Protein 1
dc.subject.enUnclassified Drug
dc.subject.enCalcium
dc.subject.enCalcium Carbonate
dc.subject.enCannabinoid Receptor Agonist
dc.subject.enGlial Fibrillary Acidic Protein
dc.subject.enIndole Derivative
dc.subject.enInterleukin 13
dc.subject.enInterleukin 2
dc.subject.enNaphthalene Derivative
dc.subject.enRantes
dc.subject.enAdolescent
dc.subject.enAdult
dc.subject.enAnimal Cell
dc.subject.enAnimal Experiment
dc.subject.enAnimal Model
dc.subject.enAnimal Tissue
dc.subject.enBehavior Assessment
dc.subject.enBehavior Disorder
dc.subject.enBrain Cortex
dc.subject.enCd-1 Mouse
dc.subject.enCompulsion
dc.subject.enControlled Study
dc.subject.enDorsal Striatum
dc.subject.enDrug Self Administration
dc.subject.enGlia Cell
dc.subject.enImmunohistochemistry
dc.subject.enImmunoreactivity
dc.subject.enMale
dc.subject.enMarble Burying Test
dc.subject.enNervous System Inflammation
dc.subject.enNeurobiology
dc.subject.enNeurochemistry
dc.subject.enNonhuman
dc.subject.enNucleus Accumbens
dc.subject.enOperant Conditioning
dc.subject.enProtein Expression
dc.subject.enReceptor Blocking
dc.subject.enReinforcement (Psychology)
dc.subject.enAnimal
dc.subject.enCalcium Carbonate
dc.subject.enCannabinoid Receptor Agonists
dc.subject.enChemokine Ccl5
dc.subject.enGlial Fibrillary Acidic Protein
dc.subject.enIndoles
dc.subject.enNaphthalenes
dc.subject.enReceptor
dc.subject.enCannabinoid
dc.subject.en4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide
dc.title.enAdolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00213-022-06191-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35943523en_US
bordeaux.journalPsychopharmacologyen_US
bordeaux.page3083-3102en_US
bordeaux.volume239en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversità degli Studi di Cagliarien_US
hal.identifierhal-03842334
hal.version1
hal.date.transferred2022-11-07T13:51:00Z
hal.exporttrue
dc.rights.ccCC BYen_US
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