dc.rights.license | open | en_US |
dc.contributor.author | MAYEN, Ana-Lucia | |
dc.contributor.author | VIALLON, Vivian | |
dc.contributor.author | BOTTERI, Edoardo | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | PROUST-LIMA, Cecile | |
dc.contributor.author | BAGNARDI, Vincenzo | |
dc.contributor.author | BATISTA, Veronica | |
dc.contributor.author | CROSS, Amanda J. | |
dc.contributor.author | LAOUALI, Nasser | |
dc.contributor.author | MACDONALD, Conor J. | |
dc.contributor.author | SEVERI, Gianluca | |
dc.contributor.author | KATZKE, Verena | |
dc.contributor.author | BERGMANN, Manuela M | |
dc.contributor.author | SCHULZE, Mattias B. | |
dc.contributor.author | TJONNELAND, Anne | |
dc.contributor.author | ERIKSEN, Anne Kirstine | |
dc.contributor.author | DAHM, Christina C. | |
dc.contributor.author | ANTONIUSSEN, Christian S. | |
dc.contributor.author | JAKSZYN, Paula | |
dc.contributor.author | SANCHEZ, Maria-Jose | |
dc.contributor.author | AMIANO, Pilar | |
dc.contributor.author | COLORADO-YOHAR, Sandra M | |
dc.contributor.author | ARDANAZ, Eva | |
dc.contributor.author | TRAVIS, Ruth | |
dc.contributor.author | PALLI, Domenico | |
dc.contributor.author | SABINA, Sieri | |
dc.contributor.author | TUMINO, Rosario | |
dc.contributor.author | RICCERI, Fulvio | |
dc.contributor.author | PANICO, Salvatore | |
dc.contributor.author | BUENO-DE-MESQUITA, Bas | |
dc.contributor.author | DERKSEN, Jeroen W. G. | |
dc.contributor.author | SONESTEDT, Emily | |
dc.contributor.author | WINKVIST, Anna | |
dc.contributor.author | HARLID, Sophia | |
dc.contributor.author | BRAATEN, Tonje | |
dc.contributor.author | GRAM, Inger Torhild | |
dc.contributor.author | LUKIC, Marko | |
dc.contributor.author | JENAB, Mazda | |
dc.contributor.author | RIBOLI, Elio | |
dc.contributor.author | FREISLING, Heinz | |
dc.contributor.author | WEIDERPASS, Elisabete | |
dc.contributor.author | GUNTER, Marc J. | |
dc.contributor.author | FERRARI, Pietro | |
dc.date.accessioned | 2022-11-02T09:25:15Z | |
dc.date.available | 2022-11-02T09:25:15Z | |
dc.date.issued | 2022-09-05 | |
dc.identifier.issn | 1573-7284 (Electronic) 0393-2990 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170185 | |
dc.description.abstractEn | BACKGROUND: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. OBJECTIVE: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. METHODS: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. RESULTS: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. CONCLUSIONS: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk. | |
dc.language.iso | EN | en_US |
dc.subject.en | Colorectal cancer | |
dc.subject.en | Alcohol change | |
dc.subject.en | Alcohol intake | |
dc.subject.en | Longitudinal exposure | |
dc.subject.en | Trajectory profile analysis | |
dc.subject.en | Latent class mixed models | |
dc.title.en | A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1007/s10654-022-00900-6 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 36063305 | en_US |
bordeaux.journal | European Journal of Epidemiology | en_US |
bordeaux.page | 915-929 | en_US |
bordeaux.volume | 37 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 9 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | BIOSTAT_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | School of Public Health, Imperial College London | en_US |
bordeaux.identifier.funderID | Danish Cancer Society Research Center | en_US |
bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
bordeaux.identifier.funderID | Institut Gustave-Roussy | en_US |
bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Medical Research Council | en_US |
bordeaux.identifier.funderID | Cancer Research UK | en_US |
bordeaux.identifier.funderID | World Cancer Research Fund | en_US |
hal.identifier | hal-03836403 | |
hal.version | 1 | |
hal.date.transferred | 2022-11-02T09:25:27Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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