Skin autofluorescence of Advanced Glycation End-products and mortality in older adults: The roles of chronic kidney disease and diabetes
| dc.rights.license | open | en_US |
| dc.contributor.author | MAJCHRZAK, Camille | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COUGNARD-GREGOIRE, Audrey | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE GOFF, Melanie
ORCID: 0000-0003-2848-6287 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cécile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | REYDIT, Mathilde | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent
IDREF: 069788146 | |
| dc.date.accessioned | 2022-10-28T09:37:35Z | |
| dc.date.available | 2022-10-28T09:37:35Z | |
| dc.date.issued | 2022-08-13 | |
| dc.identifier.issn | 0939-4753 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170136 | |
| dc.description.abstractEn | BACKGROUND AND AIM: Advanced glycation end products are involved in age-related multisystem decline. They accumulate in body tissues with age, diabetes and chronic kidney disease (CKD), and can be measured non-invasively by the skin autofluorescence (SAF). We studied the relation between SAF and later mortality in old adults. METHODS AND RESULTS: The SAF was measured using an AGE-Reader in 451 individuals from the general population aged over 75 years, and all-cause mortality was assessed during an average follow-up of 6.4 years. The association between SAF and mortality was analyzed using a multivariate Cox survival model, adjusted for age and gender. Analyses were further adjusted for diabetes and stratified on the presence of CKD due to its interaction with SAF for the risk of mortality. Participants were 82 years old on average (SD 4.1). Their mean SAF was 2.8 AU (SD 0.6). One hundred and forty-four individuals (31.9%) died during the follow-up. Adjusted for age and gender, SAF was associated with an increased risk of all-cause mortality (HR 1.44, 95%CI: 1.14-1.82 for a one-AU increase of SAF). The association was no longer significant after adjustment for diabetes. However, after stratification for the presence of CKD, higher SAF was associated with an increased risk of all-cause mortality in the participants with CKD at baseline (HR 1.68, 95%CI: 1.11-2.55), whereas there was no association among participants without CKD (HR 0.95, 95%CI: 0.63-1.44). CONCLUSION: Skin autofluorescence is associated with increased all-cause mortality in older adults already suffering from CKD. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Advanced glycation end products | |
| dc.subject.en | Skin autofluorescence | |
| dc.subject.en | Mortality | |
| dc.subject.en | Older adults | |
| dc.subject.en | Chronic kidney disease | |
| dc.subject.en | Diabetes | |
| dc.title.en | Skin autofluorescence of Advanced Glycation End-products and mortality in older adults: The roles of chronic kidney disease and diabetes | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.numecd.2022.08.009 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36064683 | en_US |
| bordeaux.journal | Nutrition, Metabolism and Cardiovascular Diseases | en_US |
| bordeaux.page | 2526-2533 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 11 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ACTIVE_BPH | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03833178 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-28T09:37:43Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrition,%20Metabolism%20and%20Cardiovascular%20Diseases&rft.date=2022-08-13&rft.volume=32&rft.issue=11&rft.spage=2526-2533&rft.epage=2526-2533&rft.eissn=0939-4753&rft.issn=0939-4753&rft.au=MAJCHRZAK,%20Camille&COUGNARD-GREGOIRE,%20Audrey&LE%20GOFF,%20Melanie&FEART-COURET,%20Catherine&DELCOURT,%20C%C3%A9cile&rft.genre=article |
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