Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
| dc.contributor.author | GARENNE, David | |
| hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
| dc.contributor.author | RENAULT, Thibaud | |
| hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
| dc.contributor.author | MANON, Stephen | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 2311-2638 | |
| dc.description.abstractEn | The heterologous expression of Bax, and other Bcl-2 family members, in the yeast Saccharomyces cerevisiae, has proved to be a valuable reporter system to investigate the molecular mechanisms underlying their interaction with mitochondria. By combining the co-expression of Bax and Bcl-xL mutants with analyzes of their localization and interaction in mitochondria and post-mitochondrial supernatants, we showed that the ability of Bax and Bcl-xL to interact is dependent both on Bax phosphorylation - mimicked by a substitution S184D - and by Bax and Bcl-xL localization. This, and previous data, provide the molecular basis for a model of dynamic equilibrium for Bax localization and activation, regulated both by phosphorylation and Bcl-xL. | |
| dc.language.iso | en | |
| dc.publisher | Shared Science Publishers OG | |
| dc.subject.en | Bax | |
| dc.subject.en | Bcl-xL | |
| dc.subject.en | mitochondria | |
| dc.subject.en | phosphorylation | |
| dc.subject.en | cytochrome c release | |
| dc.subject.en | apoptosis | |
| dc.subject.en | yeast (S.cerevisiae) | |
| dc.title.en | Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.15698/mic2016.12.547 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | |
| bordeaux.journal | Microbial Cell | |
| bordeaux.page | 597-605 | |
| bordeaux.volume | 3 | |
| bordeaux.issue | 12 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01601914 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Non spécifiée | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01601914v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microbial%20Cell&rft.date=2016&rft.volume=3&rft.issue=12&rft.spage=597-605&rft.epage=597-605&rft.eissn=2311-2638&rft.issn=2311-2638&rft.au=GARENNE,%20David&RENAULT,%20Thibaud&MANON,%20Stephen&rft.genre=article |
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