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Potential role of Mycoplasma hominis in Interleukin (IL)–17–Producing CD4+ T-Cell generation via induction of IL-23 secretion by human dendritic cells

hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorTRUCHETET, Marie-Elise
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBEVEN, Laure
hal.structure.identifierLaboratoire de Bactériologie
dc.contributor.authorRENAUDIN, Hélène
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
dc.contributor.authorDOUCHET, Isabelle
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorFÉRANDON, Cyril
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorCHARRON, Alain
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBLANCO, Patrick
hal.structure.identifierService de Rhumatologie
dc.contributor.authorSCHAEVERBEKE, Thierry
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCONTIN-BORDES, Cécile
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
hal.structure.identifierLaboratoire de Bactériologie
dc.contributor.authorBEBEAR, Cecile
dc.date.issued2011
dc.identifier.issn0022-1899
dc.description.abstractEnBackground. Mycoplasma hominis, a human urogenital pathogen, is involved in genital and extragenital infections and arthritis, particularly in immunocompromised patients. The interleukin (IL) 23/T helper (Th) 17 axis is associated with inflammatory and autoimmune diseases. The aim of this study was to assess the IL-23 response to M. hominis in human dendritic cells (DCs) and the CD4+ T-cell differentiation in response to M. hominis–infected DCs. Methods. Human monocyte–derived DCs were cultured with phosphate-buffered saline, lipopolysaccharide, or M. hominis PG21. Cocultures with heterologous T cells were performed. Extracts from M. hominis were separated and incubated with DCs. Isolates from different clinical syndromes were tested. Results. M. hominis induced the maturation of human DCs with predominant IL-23 secretion in a Toll-like receptor 2–dependent manner. The in vitro immunomodulatory capacity of M. hominis was contained in a lipoprotein-enriched fraction from the mycoplasma. M. hominis–activated DCs induced IL-17–producing CD4+ T cells. Interestingly, clinical isolates differed in their ability to promote IL-23 secretion by DCs. Conclusions. Taken together, our findings demonstrate a major role for the IL-23/Th17 axis in the defense against M. hominis and indicate a potential role for these bacteria in inflammatory and autoimmune diseases.
dc.language.isoen
dc.publisherOxford University Press
dc.subjectinfection
dc.subjectmicrobiology
dc.subjectimmunology
dc.subject.enmycoplasma
dc.subject.eninterleukin
dc.subject.enarthritis
dc.subject.eninfectious diseases
dc.title.enPotential role of Mycoplasma hominis in Interleukin (IL)–17–Producing CD4+ T-Cell generation via induction of IL-23 secretion by human dendritic cells
dc.typeArticle de revue
dc.identifier.doi10.1093/infdis/jir630
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalJournal of Infectious Diseases
bordeaux.page1796-1805
bordeaux.volume204
bordeaux.issue11
bordeaux.peerReviewedoui
hal.identifierhal-02644114
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02644114v1
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