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The tomato Guanylate-Binding Protein SlGBP1 enables fruit tissue differentiation by maintaining endopolyploid cells in a non-proliferative state

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMUSSEAU, Constance
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorJORLY, Joana
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGADIN, Stéphanie
hal.structure.identifierCornell University [New York]
dc.contributor.authorSØRENSEN, Iben
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorDEBORDE, Catherine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorBERNILLON, Stéphane
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMAUXION, Jean-Philippe
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorATIENZA, Isabelle
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorMOING, Annick
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLEMAIRE-CHAMLEY, Martine
hal.structure.identifierCornell University [New York]
dc.contributor.authorROSE, Jocelyn K.C.
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorCHEVALIER, Christian
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorROTHAN, Christophe
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorFERNANDEZ-LOCHU, Lucie
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGÉVAUDANT, Frederic
dc.date.issued2020
dc.identifier.issn1040-4651
dc.description.abstractEnCell fate maintenance is an integral part of plant cell differentiation and the production of functional cells, tissues, and organs. Fleshy fruit development is characterized by the accumulation of water and solutes in the enlarging cells of parenchymatous tissues. In tomato (Solanum lycopersicum), this process is associated with endoreduplication in mesocarp cells. The mechanisms that preserve this developmental program, once initiated, remain unknown. We show here that analysis of a previously identified tomato ethyl methanesulfonate-induced mutant that exhibits abnormal mesocarp cell differentiation could help elucidate determinants of fruit cell fate maintenance. We identified and validated the causal locus through mapping-by-sequencing and gene editing, respectively, and performed metabolic, cellular, and transcriptomic analyses of the mutant phenotype. The data indicate that disruption of the SlGBP1 gene, encoding GUANYLATE BINDING PROTEIN1, induces early termination of endoreduplication followed by late divisions of polyploid mesocarp cells, which consequently acquire the characteristics of young proliferative cells. This study reveals a crucial role of plant GBPs in the control of cell cycle genes, and thus, in cell fate maintenance. We propose that SlGBP1 acts as an inhibitor of cell division, a function conserved with the human hGBP-1 protein.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010
dc.language.isoen
dc.publisherAmerican Society of Plant Biologists (ASPB)
dc.subjectTomate
dc.subjectSolanum lycopersicum
dc.subjectDivision cellulaire
dc.subjectEndoreduplication
dc.subjectDéveloppement du fruit
dc.subjectFruit charnu
dc.title.enThe tomato Guanylate-Binding Protein SlGBP1 enables fruit tissue differentiation by maintaining endopolyploid cells in a non-proliferative state
dc.typeArticle de revue
dc.identifier.doi10.1105/tpc.20.00245
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalThe Plant cell
bordeaux.page3188-3205
bordeaux.volume32
bordeaux.issue10
bordeaux.peerReviewedoui
hal.identifierhal-02914290
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02914290v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Plant%20cell&rft.date=2020&rft.volume=32&rft.issue=10&rft.spage=3188-3205&rft.epage=3188-3205&rft.eissn=1040-4651&rft.issn=1040-4651&rft.au=MUSSEAU,%20Constance&JORLY,%20Joana&GADIN,%20St%C3%A9phanie&S%C3%98RENSEN,%20Iben&DEBORDE,%20Catherine&rft.genre=article


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