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Self-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.

hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorPERRO, Adeline
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorGIRAUD, Lauriane
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorCOUDON, Noémie
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorSHANMUGATHASAN, Sharvina
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorLAPEYRE, Véronique
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorGOUDEAU, Bertrand
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorDOULIEZ, Jean-Paul
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorRAVAINE, Valérie
dc.date.issued2019
dc.identifier.issn0021-9797
dc.description.abstractEnCoacervation is a phase separation process involving two aqueous phases, one solute-phase and one solute-poor phase. It is frequently observed among oppositely-charged polyelectrolyte systems. In this study, we focus on self-coacervation involving a single polymer chain and investigate its potential for encapsulation applications. Negatively charged polyacrylic acid polymer chains were partially cationized using diamine and carbodiimide chemistry affording ampholytes, named PAA-DA, with tunable charge ratio. When dispersed in water, at pH 7, PAA-DA was soluble but a phase separation occurs when decreasing pH close to the isoelectric point. Coacervation is found only for a given amine-to-acid ratio otherwise precipitation is observed. Increasing the pH above 4 yielded progressive destruction of the coacervates droplets via the formation of vacuoles within droplets and subsequent full homogeneous redispersion of PAA-DA in water. However, addition of calcium allowed increasing the coacervate droplet stability upon increasing the pH to 7 as the divalent ion induced gelation within droplets. Moreover, the coacervate droplets present the ability to spontaneously sequestrate a broad panel of entities, from small molecules to macromolecules or colloids, with different charges, size and hydrophobicity. Thanks to the reversible character of the coacervates, triggered-release could be easily achieved, either by varying the pH or by removing calcium ions in the case of calcium-stabilized coacervates. Self-coacervation presents the advantage of pathway-independent preparation, offering a real output interest in pharmacy, water treatment, food science or diagnostics.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.subjectSequestration
dc.subject.enSelf-coacervation
dc.subject.enWater-in-water emulsion
dc.title.enSelf-coacervation of ampholyte polymer chains as an efficient encapsulation strategy.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jcis.2019.04.033
dc.subject.halChimie/Autre
bordeaux.journalJournal of Colloid and Interface Science
bordeaux.page275-283
bordeaux.volume548
bordeaux.peerReviewedoui
hal.identifierhal-02628923
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02628923v1
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