Beware of Mycoplasma Anti-immunoglobulin Strategies
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| dc.contributor.author | ARFI, Yonathan | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| dc.contributor.author | LARTIGUE, Carole | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| dc.contributor.author | SIRAND-PUGNET, Pascal | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| dc.contributor.author | BLANCHARD, Alain | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 2161-2129 | |
| dc.description.abstractEn | Mycoplasmas are small, genome-reduced bacteria. They are obligate parasites that can be found in a wide range of host species, including the majority of livestock animals and humans. Colonization of the host can result in a wide spectrum of outcomes. In many cases, these successful parasites are considered commensal, as they are found in the microbiota of asymptomatic carriers. Conversely, mycoplasmas can also be pathogenic, as they are associated with a range of both acute and chronic inflammatory diseases which are problematic in veterinary and human medicine. The chronicity of mycoplasma infections and the ability of these bacteria to infect even recently vaccinated individuals clearly indicate that they are able to successfully evade their host's humoral immune response. Over the years, multiple strategies of immune evasion have been identified in mycoplasmas, with a number of them aimed at generating important antigenic diversity. More recently, mycoplasma-specific anti-immunoglobulin strategies have also been characterized. Through the expression of the immunoglobulin-binding proteins protein M or mycoplasma immunoglobulin binding (MIB), mycoplasmas have the ability to target the host's antibodies and to prevent them from interacting with their cognate antigens. In this review, we discuss how these discoveries shed new light on the relationship between mycoplasmas and their host's immune system. We also propose that these strategies should be taken into consideration for future studies, as they are key to our understanding of mycoplasma diseases' chronic and inflammatory nature and are probably a contributing factor to reduce vaccine efficacy. | |
| dc.description.sponsorship | Dissection moléculaire du système de clivage d'anticorps des mycoplasmes - ANR-17-CE35-0002 | |
| dc.language.iso | en | |
| dc.publisher | American Society for Microbiology | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | evasion | |
| dc.subject.en | immune evasion | |
| dc.subject.en | immunoglobulin | |
| dc.subject.en | mycoplasma | |
| dc.subject.en | persistence | |
| dc.title.en | Beware of Mycoplasma Anti-immunoglobulin Strategies | |
| dc.type | Article de revue | |
| dc.type | Article de synthèse | |
| dc.identifier.doi | 10.1128/mBio.01974-21 | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
| bordeaux.journal | mBio | |
| bordeaux.page | e01974-21 | |
| bordeaux.volume | 12 | |
| bordeaux.issue | 6 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-03440927 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-03440927v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=mBio&rft.date=2021&rft.volume=12&rft.issue=6&rft.spage=e01974-21&rft.epage=e01974-21&rft.eissn=2161-2129&rft.issn=2161-2129&rft.au=ARFI,%20Yonathan&LARTIGUE,%20Carole&SIRAND-PUGNET,%20Pascal&BLANCHARD,%20Alain&rft.genre=article&unknown |
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