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Influence of oxidized lipids on palmitoyl-oleoyl-phosphatidylcholine organization, contribution of Langmuir monolayers and Langmuir–Blodgett films

hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorGRAUBY-HEYWANG, Christine
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorMOROTÉ, Fabien
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorMATHELIÉ-GUINLET, Marion
hal.structure.identifierCellule de transfert NanoPhyNov
dc.contributor.authorGAMMOUDI, Ibtissem
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorFAYE, Ndeye Rokhaya
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorCOHEN-BOUHACINA, Touria
dc.date.created2015-09-24
dc.date.issued2016-10
dc.identifier.issn0009-3084
dc.description.abstractEnIn this work, we studied the interaction of two oxidized lipids, PoxnoPC and PazePC, with POPC phospholipid. Mean molecular areas obtained from (π–A) isotherms of mixed PoxnoPC–POPC and PazePC–POPC monolayers revealed different behaviors of these two oxidized lipids: the presence of PoxnoPC in the monolayers induces their expansion, mean molecular areas being higher than those expected in the case of ideal mixtures. PazePC–POPC behave on the whole ideally. This difference can be explained by a different conformation of oxidized lipids. Moreover the carboxylic function of PazePC is protonated under our experimental conditions, as shown by (π–A) isotherms of PazePC at different pH values. Both oxidized lipids induce also an increase of the monolayer elasticity, PoxnoPC being slightly more efficient than PazePC. These monolayers were transferred from the air–water interface onto mica supports for a study by AFM. AFM images are on the whole homogenous, suggesting the presence of only one lipid phase in both cases. However, in the case of PazePC–POPC monolayers, AFM images show also the presence of areas thicker of 7 nm to 10 nm than the surrounding lipid phase, probably due to the local formation of multilayer systems induced by compression.
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-sa/
dc.subject.enOxidized lipid
dc.subject.enLangmuir monolayer
dc.subject.enLangmuir-Blodgett film
dc.subject.enSurface pressure measurements
dc.subject.enAtomic force microscopy
dc.title.enInfluence of oxidized lipids on palmitoyl-oleoyl-phosphatidylcholine organization, contribution of Langmuir monolayers and Langmuir–Blodgett films
dc.typeArticle de revue
dc.identifier.doi10.1016/j.chemphyslip.2016.07.001
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalChemistry and Physics of Lipids
bordeaux.page74 - 82
bordeaux.volume200
bordeaux.peerReviewedoui
hal.identifierhal-01391772
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01391772v1
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