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Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations OPEN

hal.structure.identifierRégulation transcriptionnelle des génomes [GTR]
hal.structure.identifierInstitut de Biologie Intégrative de la Cellule [I2BC]
dc.contributor.authorGOLDAR, Arach
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARNEODO, A.
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierUniversité de Lyon
dc.contributor.authorAUDIT, B.
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorARGOUL, Françoise
hal.structure.identifierInstitut Pasteur [Paris] [IP]
hal.structure.identifierInstitut de biologie de l'ENS Paris [IBENS]
dc.contributor.authorRAPPAILLES, A.
hal.structure.identifierLaboratory of Molecular Biology [Cambridge]
hal.structure.identifierInstitut de biologie de l'ENS Paris [IBENS]
dc.contributor.authorGUILBAUD, G.
hal.structure.identifierInstitut de biologie de l'ENS Paris [IBENS]
hal.structure.identifierBiotech Research and Innovation Centre [BRIC]
dc.contributor.authorPETRYK, Nataliya
hal.structure.identifierInstitut de biologie de l'ENS Paris [IBENS]
dc.contributor.authorKAHLI, Malik
hal.structure.identifierInstitut de biologie de l'ENS Paris [IBENS]
dc.contributor.authorHYRIEN, Olivier
dc.date.created2015-06-26
dc.date.issued2016-03-03
dc.identifier.issn2045-2322
dc.description.abstractEnWe propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in eukaryote cell populations. By picturing replication initiation as a two-state system and considering all possible transition configurations, and by taking into account the chromatin's fractal dimension, we derive an analytical expression for the rate of replication initiation. This model predicts with no free parameter the temporal profiles of initiation rate, replication fork density and fraction of replicated DNA, in quantitative agreement with corresponding experimental data from both S. cerevisiae and human cells and provides a quantitative estimate of initiation site redundancy. This study shows that, to a large extent, the program that regulates the dynamics of eukaryotic DNA replication is a collective phenomenon that emerges from the stochastic nature of replication origins initiation.
dc.description.sponsorshipProgramme spatiotemporel de réplication du génome humain
dc.description.sponsorshipParis Sciences et Lettres - ANR-10-IDEX-0001
dc.language.isoen
dc.publisherNature Publishing Group
dc.title.enDeciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations OPEN
dc.typeArticle de revue
dc.identifier.doi10.1038/srep22469
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalScientific Reports
bordeaux.page22469 (1-8)
bordeaux.volume6
bordeaux.issue22
bordeaux.peerReviewedoui
hal.identifierhal-01412574
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01412574v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2016-03-03&rft.volume=6&rft.issue=22&rft.spage=22469%20(1-8)&rft.epage=22469%20(1-8)&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=GOLDAR,%20Arach&ARNEODO,%20A.&AUDIT,%20B.&ARGOUL,%20Fran%C3%A7oise&RAPPAILLES,%20A.&rft.genre=article


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