Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations OPEN
GOLDAR, Arach
Régulation transcriptionnelle des génomes [GTR]
Institut de Biologie Intégrative de la Cellule [I2BC]
Régulation transcriptionnelle des génomes [GTR]
Institut de Biologie Intégrative de la Cellule [I2BC]
ARNEODO, A.
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
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Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
GOLDAR, Arach
Régulation transcriptionnelle des génomes [GTR]
Institut de Biologie Intégrative de la Cellule [I2BC]
Régulation transcriptionnelle des génomes [GTR]
Institut de Biologie Intégrative de la Cellule [I2BC]
ARNEODO, A.
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
ARGOUL, Françoise
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
Laboratoire de Physique de l'ENS Lyon [Phys-ENS]
Laboratoire Ondes et Matière d'Aquitaine [LOMA]
GUILBAUD, G.
Laboratory of Molecular Biology [Cambridge]
Institut de biologie de l'ENS Paris [IBENS]
Laboratory of Molecular Biology [Cambridge]
Institut de biologie de l'ENS Paris [IBENS]
PETRYK, Nataliya
Institut de biologie de l'ENS Paris [IBENS]
Biotech Research and Innovation Centre [BRIC]
< Reduce
Institut de biologie de l'ENS Paris [IBENS]
Biotech Research and Innovation Centre [BRIC]
Language
en
Article de revue
This item was published in
Scientific Reports. 2016-03-03, vol. 6, n° 22, p. 22469 (1-8)
Nature Publishing Group
English Abstract
We propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in eukaryote cell populations. By picturing replication initiation as a ...Read more >
We propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in eukaryote cell populations. By picturing replication initiation as a two-state system and considering all possible transition configurations, and by taking into account the chromatin's fractal dimension, we derive an analytical expression for the rate of replication initiation. This model predicts with no free parameter the temporal profiles of initiation rate, replication fork density and fraction of replicated DNA, in quantitative agreement with corresponding experimental data from both S. cerevisiae and human cells and provides a quantitative estimate of initiation site redundancy. This study shows that, to a large extent, the program that regulates the dynamics of eukaryotic DNA replication is a collective phenomenon that emerges from the stochastic nature of replication origins initiation.Read less <
ANR Project
Programme spatiotemporel de réplication du génome humain - ANR-10-BLAN-1615
Paris Sciences et Lettres - ANR-10-IDEX-0001
Paris Sciences et Lettres - ANR-10-IDEX-0001
Origin
Hal imported