The role of stearic acid in ascorbic acid protection from degradation: a heterogeneous system for homogeneous thermodynamic data
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | CORVIS, Yohann | |
| hal.structure.identifier | Faculté des Sciences Pharmaceutiques et Biologiques | |
| dc.contributor.author | MENET, Marie-Claude | |
| hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
| dc.contributor.author | NÉGRIER, Philippe | |
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | LAZERGES, Mathieu | |
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | ESPEAU, Philippe | |
| dc.date.created | 2012-10-16 | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 1144-0546 | |
| dc.description.abstractEn | A heterogeneous system between vitamin C and stearic acid was characterized by thermal and crystallographic analyses. The results showed that such a system prevents vitamin C from thermal decomposition. The evidence was provided by implementing a new protocol associating chromatic assays and thermal analyses in order to quantify the percentage of non-degraded vitamin C. The results collected with the vitamin C–stearic acid mixtures allowed deducing coherent interpretation of the results obtained with pure vitamin C at different heating scan rates. Vitamin C mainly degrades upon melting but also in the solid state for temperature close to the melting point when the heating rates are very low. Under these conditions, the temperature determined at the onset of the DSC graphs cannot be associated with the melting temperature but with a fusion-degradation phenomenon. At higher scan rates, the onset as well as the endothermic value of the signal increase to reach plateau values. These values have been identified as the temperature and enthalpy values of melting of vitamin C according to the results obtained from the heterogeneous system. | |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/ | |
| dc.subject.en | solid-state stability | |
| dc.subject.en | melt-recrystallization process | |
| dc.subject.en | miscibility | |
| dc.subject.en | phase diagram | |
| dc.subject.en | polymorphism | |
| dc.subject.en | X-ray powder diffraction | |
| dc.subject.en | thermal analysis | |
| dc.subject.en | solubility | |
| dc.subject.en | drug–excipient interactions | |
| dc.title.en | The role of stearic acid in ascorbic acid protection from degradation: a heterogeneous system for homogeneous thermodynamic data | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1039/C2NJ40933J | |
| dc.subject.hal | Chimie/Cristallographie | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique | |
| bordeaux.journal | New Journal of Chemistry | |
| bordeaux.page | 761-768 | |
| bordeaux.volume | 37 | |
| bordeaux.issue | 3 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00798549 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00798549v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=New%20Journal%20of%20Chemistry&rft.date=2013&rft.volume=37&rft.issue=3&rft.spage=761-768&rft.epage=761-768&rft.eissn=1144-0546&rft.issn=1144-0546&rft.au=CORVIS,%20Yohann&MENET,%20Marie-Claude&N%C3%89GRIER,%20Philippe&LAZERGES,%20Mathieu&ESPEAU,%20Philippe&rft.genre=article |
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