The role of stearic acid in ascorbic acid protection from degradation: a heterogeneous system for homogeneous thermodynamic data
Language
en
Article de revue
This item was published in
New Journal of Chemistry. 2013, vol. 37, n° 3, p. 761-768
Royal Society of Chemistry
English Abstract
A heterogeneous system between vitamin C and stearic acid was characterized by thermal and crystallographic analyses. The results showed that such a system prevents vitamin C from thermal decomposition. The evidence was ...Read more >
A heterogeneous system between vitamin C and stearic acid was characterized by thermal and crystallographic analyses. The results showed that such a system prevents vitamin C from thermal decomposition. The evidence was provided by implementing a new protocol associating chromatic assays and thermal analyses in order to quantify the percentage of non-degraded vitamin C. The results collected with the vitamin C–stearic acid mixtures allowed deducing coherent interpretation of the results obtained with pure vitamin C at different heating scan rates. Vitamin C mainly degrades upon melting but also in the solid state for temperature close to the melting point when the heating rates are very low. Under these conditions, the temperature determined at the onset of the DSC graphs cannot be associated with the melting temperature but with a fusion-degradation phenomenon. At higher scan rates, the onset as well as the endothermic value of the signal increase to reach plateau values. These values have been identified as the temperature and enthalpy values of melting of vitamin C according to the results obtained from the heterogeneous system.Read less <
English Keywords
solid-state stability
melt-recrystallization process
miscibility
phase diagram
polymorphism
X-ray powder diffraction
thermal analysis
solubility
drug–excipient interactions
Origin
Hal imported