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A minimal rupture cascade model for living cell plasticity

hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
dc.contributor.authorPOLIZZI, Stefano
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
hal.structure.identifierLaboratoire de Biologie à Grande Échelle [BGE - UMR S1038]
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorLAPERROUSAZ, Bastien
hal.structure.identifierInstitute for Complex Systems and Mathematical Biology [Aberdeen] [ICSMB]
dc.contributor.authorPEREZ-RECHE, Francisco
hal.structure.identifierService d’Hématologie [Centre Hospitalier Lyon Sud - HCL]
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierUniversité de Lyon
dc.contributor.authorNICOLINI, Franck
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
hal.structure.identifierUniversité de Lyon
dc.contributor.authorSATTA, Véronique Maguer
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARNÉODO, Alain
hal.structure.identifierLaboratoire Ondes et Matière d'Aquitaine [LOMA]
hal.structure.identifierLaboratoire de Physique de l'ENS Lyon [Phys-ENS]
dc.contributor.authorARGOUL, Françoise
dc.date.issued2018
dc.identifier.issn1367-2630
dc.description.abstractEnUnder physiological and pathological conditions, cells experience large forces and deformations that often exceed the linear viscoelastic regime. Here we drive CD34+ cells isolated from healthy and leukemic bone marrows in the highly nonlinear elasto-plastic regime, by poking their perinuclear region with a sharp AFM cantilever tip. We use the wavelet transform mathematical microscope to identify singular events in the force-indentation curves induced by local rupture events in the cytoskeleton (CSK). We distinguish two types of rupture events, brittle failures likely corresponding to irreversible ruptures in a stiff and highly cross-linked CSK and ductile failures resulting from dynamic cross-linker unbindings during plastic deformation without loss of CSK integrity. We propose a stochastic multiplicative cascade model of mechanical ruptures that reproduces quantitatively the experimental distributions of the energy released during these events, and provides some mathematical and mechanistic understanding of the robustness of the log-normal statistics observed in both brittle and ductile situations. We also show that brittle failures are relatively more prominent in leukemia than in healthy cells suggesting their greater fragility.
dc.language.isoen
dc.publisherInstitute of Physics: Open Access Journals
dc.title.enA minimal rupture cascade model for living cell plasticity
dc.typeArticle de revue
dc.identifier.doi10.1088/1367-2630/aac3c7
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halPhysique [physics]/Mécanique [physics]/Biomécanique [physics.med-ph]
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC]
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalNew Journal of Physics
bordeaux.page053057
bordeaux.volume20
bordeaux.issue5
bordeaux.peerReviewedoui
hal.identifierhal-01803054
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01803054v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=New%20Journal%20of%20Physics&rft.date=2018&rft.volume=20&rft.issue=5&rft.spage=053057&rft.epage=053057&rft.eissn=1367-2630&rft.issn=1367-2630&rft.au=POLIZZI,%20Stefano&LAPERROUSAZ,%20Bastien&PEREZ-RECHE,%20Francisco&NICOLINI,%20Franck&SATTA,%20V%C3%A9ronique%20Maguer&rft.genre=article


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