The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation
hal.structure.identifier | Laboratoire de Physique de l'ENS Lyon [Phys-ENS] | |
dc.contributor.author | ARBONA, Jean-Michel | |
hal.structure.identifier | Régulation transcriptionnelle des génomes [GTR] | |
hal.structure.identifier | Laboratoire de Biologie Intégrative [LBI] | |
dc.contributor.author | GOLDAR, Arach | |
hal.structure.identifier | Institut de biologie de l'ENS Paris [IBENS] | |
dc.contributor.author | HYRIEN, Olivier | |
hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
hal.structure.identifier | Laboratoire de Physique de l'ENS Lyon [Phys-ENS] | |
dc.contributor.author | ARNEODO, Alain | |
hal.structure.identifier | Laboratoire de Physique de l'ENS Lyon [Phys-ENS] | |
dc.contributor.author | AUDIT, Benjamin | |
dc.date.issued | 2018-06-01 | |
dc.description.abstractEn | The time-dependent rate I(t) of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving interaction between origins and limiting firing factors. Here, we show that a normal diffusion of replication fork components towards localized potential replication origins (p-oris) can more simply account for the I(t) universal bell shape, as a consequence of a competition between the origin firing time and the time needed to replicate DNA separating two neighboring p-oris. We predict the I(t) maximal value to be the product of the replication fork speed with the squared p-ori density. We show that this relation is robustly observed in simulations and in experimental data for several eukaryotes. Our work underlines that fork-component recycling and potential origins localization are sufficient spatial ingredients to explain the universality of DNA replication kinetics. | |
dc.language.iso | en | |
dc.publisher | eLife Sciences Publication | |
dc.title.en | The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation | |
dc.type | Article de revue | |
dc.identifier.doi | 10.7554/eLife.35192 | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
dc.subject.hal | Physique [physics]/Physique [physics]/Biophysique [physics.bio-ph] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysique | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN] | |
bordeaux.journal | eLife | |
bordeaux.page | e35192 | |
bordeaux.volume | 7 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01837938 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01837938v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLife&rft.date=2018-06-01&rft.volume=7&rft.spage=e35192&rft.epage=e35192&rft.au=ARBONA,%20Jean-Michel&GOLDAR,%20Arach&HYRIEN,%20Olivier&ARNEODO,%20Alain&AUDIT,%20Benjamin&rft.genre=article |
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