p-Synephrine enantiomers: binary phase diagram, crystal structure and kinetic stability of a metastable conglomerate monitored by nonlinear optics
hal.structure.identifier | Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)] | |
dc.contributor.author | IANNO, Veronica | |
hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
dc.contributor.author | CLEVERS, Simon | |
hal.structure.identifier | Sciences et Méthodes Séparatives [SMS] | |
dc.contributor.author | NEGRIER, Philippe | |
hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
dc.contributor.author | DUPRAY, Valerie | |
hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
dc.contributor.author | COQUEREL, Gerard | |
hal.structure.identifier | Unité de Technologies Chimiques et Biologiques pour la Santé [UTCBS - UM 4 (UMR 8258 / U1267)] | |
dc.contributor.author | ESPEAU, Philippe | |
dc.date.issued | 2020 | |
dc.description.abstractEn | The crystal structure of (S)-(+)-p-synephrine was refined at 296 K from X-ray powder diffraction. The compound crystallizes in the orthorhombic systemP2(1)2(1)2(1)with four molecules per unit cell and Z ' = 1. The cell parameters are equal toa= 6.5925(12) angstrom,b= 7.9915(14) angstrom, andc= 17.035(4) angstrom. The melting characteristics of the enantiomers were determined at high DSC scan rates. The pure enantiomers melt at T-fus= 176.6 +/- 0.9 degrees C with a melting enthalpy equal to 234.2 +/- 3.9 J g(-1). Coupling DSC and crystallographic analysis, a stable binary phase diagram between these chiral molecules was established taking into account the racemic compound. Two symmetrical eutectic invariants at: 172.7 +/- 0.5 degrees C for x = 0.05 and x = 0.95 were found pretty close to the melting temperature of the enantiomers. Additionally, the equimolar mechanical mixture of the two enantiomers led to a metastable conglomerate whose melting temperature was estimated to be 149 degrees C, thanks to the Schroder-van Laar relation. The activation energy of the transition from the metastable conglomerate toward the racemic compound was estimated to be E-a = 145 kJ mol(-1)by a nonlinear optical method. This new isothermal second harmonic generation application performed at different temperatures is of general applicability for the assessment of the activation energy associated with the irreversible heterogeneous reaction: <R> + <S> -> <RS>. | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry | |
dc.subject.en | BEHAVIOR | |
dc.subject.en | ACID | |
dc.title.en | p-Synephrine enantiomers: binary phase diagram, crystal structure and kinetic stability of a metastable conglomerate monitored by nonlinear optics | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1039/d0ce00841a | |
dc.subject.hal | Physique [physics]/Physique [physics]/Chimie-Physique [physics.chem-ph] | |
dc.subject.hal | Physique [physics]/Physique [physics]/Biophysique [physics.bio-ph] | |
bordeaux.journal | CrystEngComm | |
bordeaux.page | 6071-6080 | |
bordeaux.volume | 22 | |
bordeaux.issue | 36 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03290923 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03290923v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=CrystEngComm&rft.date=2020&rft.volume=22&rft.issue=36&rft.spage=6071-6080&rft.epage=6071-6080&rft.au=IANNO,%20Veronica&CLEVERS,%20Simon&NEGRIER,%20Philippe&DUPRAY,%20Valerie&COQUEREL,%20Gerard&rft.genre=article |
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