Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission
hal.structure.identifier | Physiologie cellulaire de la synapse [PCS] | |
dc.contributor.author | HEINE, Martin | |
hal.structure.identifier | Physiologie cellulaire de la synapse [PCS] | |
dc.contributor.author | GROC, Laurent | |
hal.structure.identifier | Leibniz-Institut für Neurobiologie [LIN] | |
dc.contributor.author | FRISCHKNECHT, Renato | |
hal.structure.identifier | Department of Neuroscience | |
dc.contributor.author | BÉÏQUE, Jean-Claude | |
hal.structure.identifier | Centre de physique moléculaire optique et hertzienne [CPMOH] | |
dc.contributor.author | COGNET, Laurent | |
hal.structure.identifier | Centre de physique moléculaire optique et hertzienne [CPMOH] | |
dc.contributor.author | LOUNIS, Brahim | |
hal.structure.identifier | Department of Neuroscience | |
dc.contributor.author | RUMBAUGH, Gavin | |
hal.structure.identifier | Department of Neuroscience | |
dc.contributor.author | HUGANIR, Richard L. | |
hal.structure.identifier | Physiologie cellulaire de la synapse [PCS] | |
dc.contributor.author | CHOQUET, Daniel | |
dc.date.issued | 2008-04-11 | |
dc.identifier.issn | 0036-8075 | |
dc.description.abstractEn | AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naive functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses. | |
dc.language.iso | en | |
dc.publisher | American Association for the Advancement of Science (AAAS) | |
dc.title.en | Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1126/science.1152089 | |
bordeaux.journal | Science | |
bordeaux.page | 201-205 | |
bordeaux.volume | 320 | |
bordeaux.issue | 5873 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00747627 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00747627v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science&rft.date=2008-04-11&rft.volume=320&rft.issue=5873&rft.spage=201-205&rft.epage=201-205&rft.eissn=0036-8075&rft.issn=0036-8075&rft.au=HEINE,%20Martin&GROC,%20Laurent&FRISCHKNECHT,%20Renato&B%C3%89%C3%8FQUE,%20Jean-Claude&COGNET,%20Laurent&rft.genre=article |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |