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dc.rights.licenseopenen_US
dc.contributor.authorORIEUX, Arthur
dc.contributor.authorBRUNIER, Julien
dc.contributor.authorRIGOTHIER, Claire
dc.contributor.authorPINSON, Benoit
dc.contributor.authorDABERNAT, Sandrine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBATS, Marie-Lise
dc.date.accessioned2022-10-13T12:12:28Z
dc.date.available2022-10-13T12:12:28Z
dc.date.issued2022-01-01
dc.identifier.issn1873-3492en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/158452
dc.description.abstractEnAcute kidney injury (AKI) is an infrequent complication of inflammatory bowel disease and can be exceptionally linked to interstitial nephritis secondary to anti-inflammatory drugs, such as Pentasa® (5-ASA). We present an case of an 80-year-old man who presented chronic diarrheas treated by Pentasa®. He developed AKI, evidenced by high plasma creatinine dosed in his local laboratory. At the hospital admission, plasma creatinine was exceptionally undetectable by the enzymatic method while Jaffe's method successfully determined it. Creatinine measurement by the enzymatic method was gradually restored during hospital stay, concomitant with the discontinuation of 5-ASA administration, suggesting that this drug could interfere with creatinine enzymatic assay. Creatinine enzymatic assays combine serial reactions. The last one called Trinder reaction, catalyzed by a peroxidase, uses HO to convert uncolored dye in a colored compound, proportionally to creatinine concentration. We showed that AKI related-plasma accumulation of 5-ASA, could participate in the negative interference observed on creatinine measurement, by scavenging HO. Interestingly, all Trinder reaction-based measurements (uric acid, lipase, lactate, triglycerides and cholesterol) were affected. Negative interference of 5-ASA was confirmed by interferogram experiments on all Trinder reaction-dependent assays. All Trinder-dependent parameters should be interpreted with the patient's treatment knowledge, in particular salicylate derivatives.
dc.language.isoENen_US
dc.subject.enAcute Kidney Injury
dc.subject.enAged
dc.subject.en80 and over
dc.subject.enCreatinine
dc.subject.enHumans
dc.subject.enHydrogen Peroxide
dc.subject.enInflammatory Bowel Diseases
dc.subject.enLimit of Detection
dc.subject.enMale
dc.subject.enPeroxidase
dc.title.enPlasma creatinine below limit of quantification in a patient with acute kidney injury.
dc.title.alternativeClin Chim Actaen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cca.2021.12.001en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed34883091en_US
bordeaux.journalClinica Chimica Actaen_US
bordeaux.page101-105en_US
bordeaux.volume524en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinica%20Chimica%20Acta&rft.date=2022-01-01&rft.volume=524&rft.spage=101-105&rft.epage=101-105&rft.eissn=1873-3492&rft.issn=1873-3492&rft.au=ORIEUX,%20Arthur&BRUNIER,%20Julien&RIGOTHIER,%20Claire&PINSON,%20Benoit&DABERNAT,%20Sandrine&rft.genre=article


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