Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species
hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
dc.contributor.author | BELCOUR, Arnaud | |
hal.structure.identifier | Quadram Institute | |
hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
dc.contributor.author | FRIOUX, Clémence | |
hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
dc.contributor.author | AITE, Méziane | |
hal.structure.identifier | Plateforme bioinformatique GenOuest [Rennes] | |
hal.structure.identifier | Institut de Génétique, Environnement et Protection des Plantes [IGEPP] | |
dc.contributor.author | BRETAUDEAU, Anthony | |
hal.structure.identifier | Quadram Institute | |
hal.structure.identifier | Earlham Institute [Norwich] | |
dc.contributor.author | HILDEBRAND, Falk | |
hal.structure.identifier | Dynamics, Logics and Inference for biological Systems and Sequences [Dyliss] | |
dc.contributor.author | SIEGEL, Anne | |
dc.date.issued | 2020-12-29 | |
dc.description.abstractEn | To capture the functional diversity of microbiota, one must identify metabolic functions and species of interest within hundreds or thousands of microorganisms. We present Metage2Metabo (M2M) a resource that meets the need for de-novo functional screening of genome-scale metabolic networks (GSMNs) at the scale of a metagenome, and the identification of critical species with respect to metabolic cooperation. M2M comprises a flexible pipeline for the characterisation of individual metabolisms and collective metabolic complementarity. In addition, M2M identifies key species, that are meaningful members of the community for functions of interest. We demonstrate that M2M is applicable to collections of genomes as well as metagenome-assembled genomes, permits an efficient GSMN reconstruction with Pathway Tools, and assesses the cooperation potential between species. M2M identifies key organisms by reducing the complexity of a large-scale microbiota into minimal communities with equivalent properties, suitable for further analyses. | |
dc.description.sponsorship | Biotechnologies pour la valorisation des macroalgues - ANR-10-BTBR-0004 | |
dc.language.iso | en | |
dc.publisher | eLife Sciences Publication | |
dc.subject.en | computational biology | |
dc.subject.en | human | |
dc.subject.en | keystone species | |
dc.subject.en | metabolic complementarity | |
dc.subject.en | metabolic modelling | |
dc.subject.en | metagenomics | |
dc.subject.en | microbiota | |
dc.subject.en | systems biology | |
dc.title.en | Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species | |
dc.type | Article de revue | |
dc.identifier.doi | 10.7554/eLife.61968 | |
dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM] | |
bordeaux.journal | eLife | |
bordeaux.volume | 9 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02395024 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02395024v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLife&rft.date=2020-12-29&rft.volume=9&rft.au=BELCOUR,%20Arnaud&FRIOUX,%20Cl%C3%A9mence&AITE,%20M%C3%A9ziane&BRETAUDEAU,%20Anthony&HILDEBRAND,%20Falk&rft.genre=article |
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