Afficher la notice abrégée

Testosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome

dc.rights.licenseopenen_US
dc.contributor.authorLAOUALI, N.
dc.contributor.authorBRAILLY-TABARD, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorANCELIN, M. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorSINGH-MANOUX, A.
dc.contributor.authorDUGRAVOT, A.
dc.contributor.authorELBAZ, A.
dc.contributor.authorGUIOCHON-MANTEL, A.
dc.contributor.authorCANONICO, M.
dc.date.accessioned2020-11-23T15:57:51Z
dc.date.available2020-11-23T15:57:51Z
dc.date.issued2018-04-01
dc.identifier.issn2472-1972 (Electronic) 2472-1972 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/15588
dc.description.abstractEnPrevious studies have shown controversial results about the role of testosterone in all-cause mortality in elderly men. We hypothesized that metabolic syndrome (MetS) could partly explain this discrepancy. We therefore examined the association of all-cause mortality with total and bioavailable testosterone, taking into account the MetS. We used data from the Three-City Cohort (3C) study with 12-year follow-up. The 3C study included 3650 men aged >65 years in three French cities. Hormone was measured in a random subsample of 444 men, and MetS was determined as stated by the International Diabetes Federation criteria. We used inverse-probability-weighted Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). Of 444 men included in the analysis, 106 (23.9%) had MetS at baseline, and 166 died over the follow-up. There was a significant interaction between testosterone level and MetS for all-cause mortality (P = 0.002 and P = 0.008 for total and bioavailable testosterone, respectively). Among men with MetS, a decrease in one standard deviation of testosterone was associated with higher mortality risk [HR 1.78 (95% CI 1.13 to 2.78) and HR 1.83 (95% CI 1.17 to 2.86) for total and bioavailable testosterone, respectively]. By contrast, there was no association of testosterone with mortality risk among men without MetS. Our results suggest that MetS modifies the association between testosterone and mortality in older men. If confirmed, these findings could contribute to improve risk stratification and better manage the health of older men.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enLEHA
dc.subject.enVINTAGE
dc.title.enTestosterone and All-Cause Mortality in Older Men: The Role of Metabolic Syndrome
dc.title.alternativeJ Endocr Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1210/js.2018-00005en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29577108en_US
bordeaux.journalJournal of the Endocrine Societyen_US
bordeaux.page322-335en_US
bordeaux.volume2en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamLEHA_BPH
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03164948
hal.version1
hal.date.transferred2021-03-10T11:07:01Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20Endocrine%20Society&rft.date=2018-04-01&rft.volume=2&rft.issue=4&rft.spage=322-335&rft.epage=322-335&rft.eissn=2472-1972%20(Electronic)%202472-1972%20(Linking)&rft.issn=2472-1972%20(Electronic)%202472-1972%20(Linking)&rft.au=LAOUALI,%20N.&BRAILLY-TABARD,%20S.&HELMER,%20Catherine&ANCELIN,%20M.%20L.&TZOURIO,%20Christophe&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_JES_2018_Laouali.pdf
Taille:
374.1Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
811octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée