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Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease

dc.rights.licenseopenen_US
dc.contributor.authorKERBER, R.
dc.contributor.authorKRUMKAMP, R.
dc.contributor.authorKORVA, M.
dc.contributor.authorRIEGER, T.
dc.contributor.authorWURR, S.
dc.contributor.authorDURAFFOUR, S.
dc.contributor.authorOESTEREICH, L.
dc.contributor.authorGABRIEL, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSISSOKO, Daouda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALVY, Denis
dc.contributor.authorMAY, J.
dc.contributor.authorZUPANC, T. A.
dc.contributor.authorMUNOZ-FONTELA, C.
dc.contributor.authorGUNTHER, S.
dc.date.accessioned2020-11-23T10:42:13Z
dc.date.available2020-11-23T10:42:13Z
dc.date.issued2018-11-22
dc.identifier.issn1537-6613 (Electronic) 0022-1899 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/15566
dc.description.abstractEnBackground: The pathophysiology of Ebola virus disease (EVD) is still poorly understood. This study aimed at identifying soluble biomarkers that inform on disease mechanisms. Methods: Fifty-four soluble mediators of the immune, coagulation, and endothelial system were measured in baseline and follow-up samples from hospitalized patients with EVD, using Luminex technology. Cross-sectional expression levels and changes over time were correlated with outcome. Results: Levels of circulating proinflammatory cytokines and chemokines, as well as markers of endothelial dysfunction and coagulopathy, were elevated on admission to hospital in patients who died from EVD as compared to survivors. These markers further increased in patients who died and/or decreased over time in survivors. In contrast, markers of gut integrity and T-cell response were higher in survivors and increased until discharge. Conclusions: Inflammatory response, endothelial integrity, gastric tissue protection, and T cell immunity play a role in EVD pathophysiology.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enIDLIC
dc.subject.enPACCI
dc.title.enKinetics of Soluble Mediators of the Host Response in Ebola Virus Disease
dc.title.alternativeJ Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/infdis/jiy429en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30101349en_US
bordeaux.journalThe Journal of Infectious Diseasesen_US
bordeaux.pageS496-S503en_US
bordeaux.volume218en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issueSuppl 5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.teamPACCIen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03164909
hal.version1
hal.date.transferred2021-03-10T10:58:29Z
hal.exporttrue
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