Malnutrition, Growth Response and Metabolic Changes Within the First 24 Months After ART Initiation in HIV-infected Children Treated Before the Age of 2 Years in West Africa
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | JESSON, Julie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DAHOUROU, Desire Lucien | |
| dc.contributor.author | AMORISSANI FOLQUET, M. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MALATESTE, Karen | |
| dc.contributor.author | YONABA, C. | |
| dc.contributor.author | N'GBECHE, M. S. | |
| dc.contributor.author | OUEDRAOGO, S. | |
| dc.contributor.author | MEA-ASSANDE, V. | |
| dc.contributor.author | AMANI-BOSSE, C. | |
| dc.contributor.author | BLANCHE, S. | |
| dc.contributor.author | TIMITE-KONAN, M. | |
| dc.contributor.author | LEROY, V. | |
| dc.date.accessioned | 2020-11-23T08:21:30Z | |
| dc.date.available | 2020-11-23T08:21:30Z | |
| dc.date.issued | 2018-08 | |
| dc.identifier.issn | 1532-0987 (Electronic) 0891-3668 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/15559 | |
| dc.description.abstractEn | BACKGROUND: There is limited information about malnutrition, growth evolution and metabolic changes among children initiated early on lopinavir-based antiretroviral therapy (ART) in Africa. METHODS: HIV-1-infected children, age <2 years were initiated on ART, as part of the MONOD ANRS 12206 project, conducted in Burkina Faso and Cote d'Ivoire. Weight-for-age, height-for-age and weight-for-height Z-scores (WAZ, HAZ, WHZ) defined malnutrition (Z-score <-2 standard deviations [SD]) using WHO growth references. Biological data were collected every 6 months. Factors associated with baseline malnutrition were evaluated using multivariate logistic regression, and with growth evolution in the first 24 months on ART using linear mixed models. RESULTS: Between 2011 and 2013, 161 children were enrolled: 64% were from Abidjan, 54% were girls. At ART initiation, median age was 13.7 months [IQR 7.7; 18.4], 52% were underweight (WAZ), 52% were stunted (HAZ), and 36% were wasted (WHZ). Overall, baseline malnutrition was more likely for children living in Burkina Faso, with low birth-weight, never breastfed, and older age (12-24 months). Growth improved on ART, mainly within the first 6 months for weight, and was greater for the most severely malnourished children at baseline, but 8% to 32% remained malnourished after 24 months. Over the 24-month period of ART, there was a significant increase of hypercholesterolemia and decrease of anemia and hypoalbuminemia. CONCLUSIONS: Prevalence of malnutrition was high before ART initiation. Even though growth improved on ART, some children remained malnourished even after 2 years of ART, highlighting the need for more active nutritional support. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | IDLIC | |
| dc.title.en | Malnutrition, Growth Response and Metabolic Changes Within the First 24 Months After ART Initiation in HIV-infected Children Treated Before the Age of 2 Years in West Africa | |
| dc.title.alternative | Pediatr Infect Dis J | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/inf.0000000000001932 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29406463 | en_US |
| bordeaux.journal | The Pediatric Infectious Disease Journal | en_US |
| bordeaux.page | 781-787 | en_US |
| bordeaux.volume | 37 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03194266 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-09T12:12:13Z | |
| hal.export | true | |
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