Show simple item record

Thermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core-corona nanoparticles as a drug delivery system

hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLIU, Ji
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorDETREMBLEUR, Christophe
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorHURTGEN, Marie
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorDEBUIGNE, Antoine
hal.structure.identifierLaboratory of Mammalian Cell Culture [GIGA-R]
dc.contributor.authorDE PAUW-GILLET, Marie-Claire
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Christine
dc.date.issued2014
dc.identifier.issn1759-9954
dc.description.abstractEnCore-corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous solution. Arrangement of macromolecular chains on the surface of gold cores was studied by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy and infrared spectroscopy. The responsiveness to temperature and the preserved colloidal stability of the gold@PVOH-b-PNVCL NPs above the lower critical solution temperature (LCST) were confirmed by dynamic light scattering and turbidity measurements. The drug loading capacity (DLC of ca. 1.3-2.8 wt%) of the gold@PVOH-b-PNVCL NPs as a drug delivery system (DDS) was tested with Nadolol®, a hydrophilic drug, and the release behaviours were studied at several temperatures. PVOH-b-PNVCL copolymers with an LCST of a few degrees above the biological temperature (37 °C), for example, PVOH180-b-PNVCL110 (LCST of 41 °C), are preferential, due to the slower release at 37 °C, but a faster release at temperatures that are a few degrees higher. The cytocompatibility of the gold@PVOH-b-PNVCL NPs against mouse fibroblastic L929 cells was evaluated via the MTS assay. Cellular uptake within MEL-5 human melanoma cells was studied by confocal laser scanning microscopy, fluorescence-activated cell sorting and TEM techniques and it showed that gold@PVOH-b-PNVCL NPs preferably accumulated within the cellular cytoplasm, with an incubation concentration and period-dependent uptake process. All these results corroborated a general utility of these thermo-responsive gold@PVOH-b-PNVCL NPs for drug delivery and controlled drug release.
dc.language.isoen
dc.publisherRoyal Society of Chemistry - RSC
dc.title.enThermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core-corona nanoparticles as a drug delivery system
dc.typeArticle de revue
dc.identifier.doi10.1039/c4py00352g
dc.subject.halChimie/Matériaux
bordeaux.journalPolymer Chemistry
bordeaux.page5289-5299
bordeaux.volume5
bordeaux.issue18
bordeaux.peerReviewedoui
hal.identifierhal-01059137
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01059137v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2014&rft.volume=5&rft.issue=18&rft.spage=5289-5299&rft.epage=5289-5299&rft.eissn=1759-9954&rft.issn=1759-9954&rft.au=LIU,%20Ji&DETREMBLEUR,%20Christophe&HURTGEN,%20Marie&DEBUIGNE,%20Antoine&DE%20PAUW-GILLET,%20Marie-Claire&rft.genre=article


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record