The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers
hal.structure.identifier | Physico-chimie, pharmacotechnie, biopharmacie [PCPB] | |
dc.contributor.author | BRIGGER, Irène | |
hal.structure.identifier | Laboratoire de Bactériologie | |
dc.contributor.author | ARMAND-LEFEVRE, Laurence | |
hal.structure.identifier | Groupe de Chimie Analytique de Paris-Sud | |
dc.contributor.author | CHAMINADE, Pierre | |
hal.structure.identifier | Physico-chimie, pharmacotechnie, biopharmacie [PCPB] | |
dc.contributor.author | BESNARD, Madeleine | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | RIGALDIE, Yohan | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | LARGETEAU, Alain | |
hal.structure.identifier | Physico-chimie, pharmacotechnie, biopharmacie [PCPB] | |
hal.structure.identifier | Laboratoire de Bactériologie | |
dc.contributor.author | ANDREMONT, Antoine | |
hal.structure.identifier | Ellipse Pharmaceutical | |
dc.contributor.author | GRISLAIN, Luc | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | DEMAZEAU, Gérard | |
hal.structure.identifier | Physico-chimie, pharmacotechnie, biopharmacie [PCPB] | |
dc.contributor.author | COUVREUR, Patrick | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0724-8741 | |
dc.description.abstractEn | To investigate whether high hydrostatic pressure (HHP) treatment allows the sterilization of thermosensitive polymer nanoparticle suspensions without jeopardizing their physicochemical integrity. METHODS: Application of HHP was explored on a wide variety of thermosensitive poly(cyanoacrylate) nanoparticles, varying by their type (nanospheres or nanocapsules), by their preparation method (nanoprecipitation or emulsion/solvent evaporation), as well as by their surface characteristics. Physicochemical characterization before and after pressurization included turbidimetry, size measurement, zeta potential, scanning electron microscopy and infrared analysis. A sterility test also conducted according to pharmacopoeial requirements on an importantly contaminated nanoparticle suspension. RESULTS: Poly(cyanoacrylate) nanoparticles appeared to be extremely baroresistant. Continuous or oscillatory HHP treatment up to 500 MPa during 30 min induced generally neither physical, nor chemical damage. However, precautions should be taken when surface modifiers are adsorbed onto nanoparticles, as a layer destabilization may occur. Finally, this process allowed the successful inactivation of vegetative bacteria, yeast, and fungi. CONCLUSIONS: This work proposes HHP as a new method for polymer drug carriers sterilization, taking into account that further exploration in this area is needed to propose novel protocols for spores inactivation. | |
dc.language.iso | en | |
dc.publisher | American Association of Pharmaceutical Scientists | |
dc.subject.en | High hydrostatic pressure processing | |
dc.subject.en | Nanoparticles | |
dc.subject.en | Poly(cyanoacrylate) | |
dc.subject.en | Sterilization | |
dc.subject.en | Surface modifiers | |
dc.title.en | The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1023/A:1023267304096 | |
dc.subject.hal | Chimie/Matériaux | |
dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques | |
bordeaux.journal | Pharmaceutical Research | |
bordeaux.page | 674-683 | |
bordeaux.volume | 20 | |
bordeaux.issue | 4 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00238466 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00238466v1 | |
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