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The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers

hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
dc.contributor.authorBRIGGER, Irène
hal.structure.identifierLaboratoire de Bactériologie
dc.contributor.authorARMAND-LEFEVRE, Laurence
hal.structure.identifierGroupe de Chimie Analytique de Paris-Sud
dc.contributor.authorCHAMINADE, Pierre
hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
dc.contributor.authorBESNARD, Madeleine
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorRIGALDIE, Yohan
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLARGETEAU, Alain
hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
hal.structure.identifierLaboratoire de Bactériologie
dc.contributor.authorANDREMONT, Antoine
hal.structure.identifierEllipse Pharmaceutical
dc.contributor.authorGRISLAIN, Luc
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDEMAZEAU, Gérard
hal.structure.identifierPhysico-chimie, pharmacotechnie, biopharmacie [PCPB]
dc.contributor.authorCOUVREUR, Patrick
dc.date.issued2003
dc.identifier.issn0724-8741
dc.description.abstractEnTo investigate whether high hydrostatic pressure (HHP) treatment allows the sterilization of thermosensitive polymer nanoparticle suspensions without jeopardizing their physicochemical integrity. METHODS: Application of HHP was explored on a wide variety of thermosensitive poly(cyanoacrylate) nanoparticles, varying by their type (nanospheres or nanocapsules), by their preparation method (nanoprecipitation or emulsion/solvent evaporation), as well as by their surface characteristics. Physicochemical characterization before and after pressurization included turbidimetry, size measurement, zeta potential, scanning electron microscopy and infrared analysis. A sterility test also conducted according to pharmacopoeial requirements on an importantly contaminated nanoparticle suspension. RESULTS: Poly(cyanoacrylate) nanoparticles appeared to be extremely baroresistant. Continuous or oscillatory HHP treatment up to 500 MPa during 30 min induced generally neither physical, nor chemical damage. However, precautions should be taken when surface modifiers are adsorbed onto nanoparticles, as a layer destabilization may occur. Finally, this process allowed the successful inactivation of vegetative bacteria, yeast, and fungi. CONCLUSIONS: This work proposes HHP as a new method for polymer drug carriers sterilization, taking into account that further exploration in this area is needed to propose novel protocols for spores inactivation.
dc.language.isoen
dc.publisherAmerican Association of Pharmaceutical Scientists
dc.subject.enHigh hydrostatic pressure processing
dc.subject.enNanoparticles
dc.subject.enPoly(cyanoacrylate)
dc.subject.enSterilization
dc.subject.enSurface modifiers
dc.title.enThe stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers
dc.typeArticle de revue
dc.identifier.doi10.1023/A:1023267304096
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
bordeaux.journalPharmaceutical Research
bordeaux.page674-683
bordeaux.volume20
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierhal-00238466
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00238466v1
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