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Search for tumor-specific frequencies of amplitude-modulated 27 MHz electromagnetic fields in mice with hepatocarcinoma xenografted tumors

hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
hal.structure.identifierCNRS, PSL Research University, EPHE
dc.contributor.authorVEYRET, Bernard
hal.structure.identifierBIO-INGENIERIE [XLIM-BIO-INGENIERIE]
hal.structure.identifierInstitut universitaire de France [IUF]
dc.contributor.authorARNAUD-CORMOS, Delia
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPOQUE, Emmanuelle
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPOULLETIER DE GANNES, Florence
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorHURTIER, Annabelle
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDECOURT, Rodolphe
hal.structure.identifierELORGA
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorKHIEV, Sokha
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorN’KAOUA, Gilles
hal.structure.identifierCNRS, PSL Research University, EPHE
dc.contributor.authorLAGROYE, Isabelle
hal.structure.identifierBIO-INGENIERIE [XLIM-BIO-INGENIERIE]
dc.contributor.authorLÉVÊQUE, Philippe
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPERCHERANCIER, Yann
dc.date.issued2019-11-20
dc.identifier.issn0955-3002
dc.description.abstractEnAim: The Pasche research group has reported that tumor-specific electromagnetic field frequencies have physiological and potential anti-tumor effects in cells, animals, and humans. Our aim was to investigate whether these fields have similar effects on physiological parameters in murine tumor models. Methods: Human HuH7 or HEPG2 cells were implanted in the right flank of 8-week-old female RAG gamma 2C immunodeficient mice. An oximeter was used to record systolic blood pressure (pulse) in free-roaming conscious mice. Mice pulses were recorded and analyzed using a in-house software that also controlled the low-frequency generator for modulating the 27.12 MHz carrier wave at selected frequencies. Results: We performed exposures using both systematic scans at low-frequencies and at the predetermined frequencies reported by the Pasche group as altering both pulse and tumor growth in humans. Those exposures produced no detectable change in physiological parameters of tumor-bearing mice. Conclusion: No tumor-related frequencies were found, neither using systematic scans of frequencies nor published specific frequencies. There might obviously be differences between animal and human models, but our approach did not confirm the physiological data of the human Pasche group data.
dc.language.isoen
dc.publisherTaylor and Francis
dc.title.enSearch for tumor-specific frequencies of amplitude-modulated 27 MHz electromagnetic fields in mice with hepatocarcinoma xenografted tumors
dc.typeArticle de revue
dc.identifier.doi10.1080/09553002.2020.1694191
dc.subject.halPhysique [physics]/Physique [physics]
dc.subject.halSciences du Vivant [q-bio]/Toxicologie
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
dc.subject.halSciences de l'ingénieur [physics]/Electromagnétisme
bordeaux.journalInternational Journal of Radiation Biology
bordeaux.page411-418
bordeaux.volume96
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-02459242
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02459242v1
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