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Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.

dc.contributor.authorOUMZIL, Khalid
dc.contributor.authorRAMIN, Michael A.
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorLORENZATO, Cyril
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorHÉMADOU, Audrey
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorLAROCHE, Jeanny
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorJACOBIN-VALAT, Marie Josée
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
dc.contributor.authorROY, Claude-Eric
dc.contributor.authorKAUSS, Tina
dc.contributor.authorGAUDIN, Karen
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCLOFENT-SANCHEZ, Gisèle
dc.contributor.authorBARTHÉLÉMY, Philippe
dc.date.issued2016-03-16
dc.identifier.issn1043-1802
dc.description.abstractEnAlthough the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enSolid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.bioconjchem.5b00590
dc.subject.halChimie/Matériaux
bordeaux.journalBioconjugate Chemistry
bordeaux.page569-575
bordeaux.volume27
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-01296329
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01296329v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioconjugate%20Chemistry&rft.date=2016-03-16&rft.volume=27&rft.issue=3&rft.spage=569-575&rft.epage=569-575&rft.eissn=1043-1802&rft.issn=1043-1802&rft.au=OUMZIL,%20Khalid&RAMIN,%20Michael%20A.&LORENZATO,%20Cyril&H%C3%89MADOU,%20Audrey&LAROCHE,%20Jeanny&rft.genre=article


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