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The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCHAUVEAU, Bertrand
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorRAYMOND, Anne-Aurélie
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorDI TOMMASO, Sylvaine
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
dc.contributor.authorVERMOREL, Agathe
dc.contributor.authorDUGOT-SENANT, Nathalie
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorDOURTHE, Cyril
dc.contributor.authorDUPUY, Jean-William
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorDÉCHANET-MERVILLE, Julie
dc.contributor.authorDUONG VAN HUYEN, Jean-Paul
dc.contributor.authorRABANT, Marion
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
hal.structure.identifierTBM-Core [Bordeaux] [UMS3427 - INSERM US005]
dc.contributor.authorSALTEL, Frédéric
ORCID: 0000-0002-0724-9680
IDREF: 089053079
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
dc.date.accessioned2022-10-12T08:47:13Z
dc.date.available2022-10-12T08:47:13Z
dc.date.issued2022-02-28
dc.identifier.issn2227-9059en_US
dc.identifier.otherhttps: //www.mdpi.com/article/10.3390/biomedicines10030569/s1en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/150185
dc.description.abstractEnAntibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplantation. Its histological hallmark is represented by lesions of glomerulitis i.e., inflammatory cells within glomeruli. Current therapies for ABMR fail to prevent chronic allograft damage i.e., transplant glomerulopathy, leading to allograft loss. We used laser microdissection of glomeruli from formalin-fixed allograft biopsies combined with mass spectrometry-based proteomics to describe the proteome modification of 11 active and 10 chronic active ABMR cases compared to 8 stable graft controls. Of 1335 detected proteins, 77 were deregulated in glomerulitis compared to stable grafts, particularly involved in cellular stress mediated by interferons type I and II, leukocyte activation and microcirculation remodeling. Three proteins extracted from this protein profile, TYMP, WARS1 and GBP1, showed a consistent overexpression by immunohistochemistry in glomerular endothelial cells that may represent relevant markers of endothelial stress during active ABMR. In transplant glomerulopathy, 137 proteins were deregulated, which favor a complement-mediated mechanism, wound healing processes through coagulation activation and ultimately a remodeling of the glomerular extracellular matrix, as observed by light microscopy. This study brings novel information on glomerular proteomics of ABMR in kidney transplantation, and highlights potential targets of diagnostic and therapeutic interest.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enThe Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy
dc.title.alternativeBiomedicinesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/biomedicines10030569en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologie
dc.identifier.pubmed35327371en_US
bordeaux.journalBiomedicinesen_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesTBM-Core [Bordeaux] [CNRS UMS 3427 - INSERM US 005]en_US
bordeaux.hal.laboratoriesImmunology from Concept and Experiments to Translation [ImmunoConcept]en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03962556
hal.version1
hal.date.transferred2023-01-30T10:44:32Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicines&rft.date=2022-02-28&rft.volume=10&rft.issue=3&rft.eissn=2227-9059&rft.issn=2227-9059&rft.au=CHAUVEAU,%20Bertrand&RAYMOND,%20Anne-Aur%C3%A9lie&DI%20TOMMASO,%20Sylvaine&VISENTIN,%20Jonathan&VERMOREL,%20Agathe&rft.genre=article


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