Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | LIU, Ji | |
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| dc.contributor.author | DETREMBLEUR, Christophe | |
| hal.structure.identifier | Laboratory of Mammalian Cell Culture [GIGA-R] | |
| dc.contributor.author | DE PAUW-GILLET, Marie-Claire | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | MORNET, Stéphane | |
| hal.structure.identifier | NMR Laboratory, Université de Mons | |
| dc.contributor.author | VANDER ELST, Luce | |
| hal.structure.identifier | NMR Laboratory, Université de Mons | |
| dc.contributor.author | LAURENT, Sophie | |
| hal.structure.identifier | Centre d'Etude et de Recherche sur les Macromolécules [CERM] | |
| dc.contributor.author | JÉRÔME, Christine | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | DUGUET, Etienne | |
| dc.date.issued | 2014 | |
| dc.description.abstractEn | Core-shell nanoparticles made of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a "zero premature release" (<3% of the entire payload in 96 h release) under physiological conditions (37 °C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heat-triggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after 72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core-shell nanoparticles are envisaged to become promising DDS for "on-demand" heat-triggered release. | |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry | |
| dc.subject.en | Core-shell | |
| dc.subject.en | Nanoparticles | |
| dc.subject.en | Maghemite | |
| dc.subject.en | Mesoporous materials | |
| dc.subject.en | Silica | |
| dc.subject.en | Drug delivery systems | |
| dc.title.en | Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1039/c3tb21229g | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie | |
| bordeaux.journal | Journal of Materials Chemistry B: Materials for Biology and Medicine | |
| bordeaux.page | 59-70 | |
| bordeaux.volume | 2 | |
| bordeaux.issue | 1 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00923633 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00923633v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Materials%20Chemistry%20B:%20Materials%20for%20Biology%20and%20Medicine&rft.date=2014&rft.volume=2&rft.issue=1&rft.spage=59-70&rft.epage=59-70&rft.au=LIU,%20Ji&DETREMBLEUR,%20Christophe&DE%20PAUW-GILLET,%20Marie-Claire&MORNET,%20St%C3%A9phane&VANDER%20ELST,%20Luce&rft.genre=article |
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