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Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring

hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOLNOT, Eloïse
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCARDOIT, Laura
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCABIROL, Marie-Jeanne
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorROUDIER, Lydia
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDELVILLE, Marie-Hélène
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorFAYOUX, Anne
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorTHOBY-BRISSON, Muriel
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorJUVIN, Laurent
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMORIN, Didier
dc.date.issued2022
dc.identifier.issn1743-8977
dc.description.abstractEnBackground: Over the last two decades, nanotechnologies and the use of nanoparticles represent one of the greatest technological advances in many fields of human activity. Particles of titanium dioxide (TiO 2) are one of the nanomaterials most frequently found in everyday consumer products. But, due in particular to their extremely small size, TiO 2 nanoparticles (NPs) are prone to cross biological barriers and potentially lead to adverse health effects. The presence of TiO 2 NPs found in human placentae and in the infant meconium has indicated unequivocally the capacity for a materno-fetal transfer of this nanomaterial. Although chronic exposure to TiO 2 NPs during pregnancy is known to induce offspring cognitive deficits associated with neurotoxicity, the impact of a gestational exposure on a vital motor function such as respiration, whose functional emergence occurs during fetal development, remains unknown.Results: Using in vivo whole-body plethysmographic recordings from neonatal mice, we show that a chronic exposure to TiO 2 NPs during pregnancy alters the respiratory activity of offspring, characterized by an abnormally elevated rate of breathing. Correspondingly, using ex vivo electrophysiological recordings performed on isolated brainstemspinal cord preparations of newborn mice and medullary slice preparations containing specific nuclei controlling breathing frequency, we show that the spontaneously generated respiratory-related rhythm is significantly and abnormally accelerated in animals prenatally exposed to TiO 2 NPs. Moreover, such a chronic prenatal exposure was found to impair the capacity of respiratory neural circuitry to effectively adjust breathing rates in response to excitatory environmental stimuli such as an increase in ambient temperature.Conclusions: Our findings thus demonstrate that a maternal exposure to TiO 2 NPs during pregnancy affects the normal development and operation of the respiratory centers in progeny.
dc.language.isoen
dc.publisherBioMed Central
dc.subject.enTitanium dioxide nanoparticles
dc.subject.enMaternal exposure
dc.subject.enRespiration
dc.subject.enMouse
dc.subject.enNervous system development
dc.subject.enNeurotoxicity
dc.subject.meshAdult
dc.subject.meshAffect
dc.subject.meshSocial Behavior
dc.subject.meshSubstance Withdrawal Syndrome
dc.subject.meshCaffeine
dc.subject.meshCentral Nervous System Stimulants
dc.subject.meshEating
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPsychomotor Performance
dc.title.enChronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring
dc.typeArticle de revue
dc.identifier.doi10.1186/s12989-022-00497-4
dc.subject.halSciences du Vivant [q-bio]/Toxicologie
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Pédiatrie
bordeaux.journalParticle and Fibre Toxicology
bordeaux.page57
bordeaux.volume19
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierhal-03759564
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03759564v1
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